Combining micro computed tomography and three-dimensional registration to evaluate local strains in shape memory scaffolds

被引:22
作者
Bormann, Therese [1 ,2 ]
Schulz, Georg [1 ]
Deyhle, Hans [1 ]
Beckmann, Felix [3 ]
de Wild, Michael [2 ]
Kueffer, Juerg [4 ]
Muench, Christoph [4 ]
Hoffmann, Waldemar [2 ]
Mueller, Bert [1 ]
机构
[1] Univ Basel, Univ Basel Hosp, Biomat Sci Ctr, CH-4031 Basel, Switzerland
[2] Univ Appl Sci & Arts Northwestern Switzerland, Sch Life Sci, Inst Med & Analyt Technol, CH-4032 Muttenz, Switzerland
[3] Helmholtz Zentrum Geesthacht, Inst Mat Res, D-21502 Geesthacht, Germany
[4] Univ Appl Sci & Arts Northwestern Switzerland, Sch Engn, Inst Prod & Prod Engn, CH-5210 Windisch, Switzerland
基金
瑞士国家科学基金会;
关键词
NiTi; Scaffold compression; Variable temperature tomography; Digital volume correlation; Three-dimensional displacement field; DIGITAL VOLUME CORRELATION; FINITE-ELEMENT; POROUS NITI; GENE-EXPRESSION; BONE-FORMATION; STROMAL CELLS; DIFFERENTIATION; PROLIFERATION; DISPLACEMENTS; STIMULI;
D O I
10.1016/j.actbio.2013.11.007
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Appropriate mechanical stimulation of bony tissue enhances osseointegration of load-bearing implants. Uniaxial compression of porous implants locally results in tensile and compressive strains. Their experimental determination is the objective of this study. Selective laser melting is applied to produce open-porous NiTi scaffolds of cubic units. To measure displacement and strain fields within the compressed scaffold, the authors took advantage of synchrotron radiation-based micro computed tomography during temperature increase and non-rigid three-dimensional data registration. Uniaxial scaffold compression of 6% led to local compressive and tensile strains of up to 15%. The experiments validate modeling by means of the finite element method. Increasing the temperature during the tomography experiment from 15 to 37 degrees C at a rate of 4K h(-1), one can locally identify the phase transition from martensite to austenite. It starts at similar to 24 degrees C on the scaffolds bottom, proceeds up towards the top and terminates at similar to 34 degrees C on the periphery of the scaffold. The results allow not only design optimization of the scaffold architecture, but also estimation of maximal displacements before cracks are initiated and of optimized mechanical stimuli around porous metallic load-bearing implants within the physiological temperature range. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:1024 / 1034
页数:11
相关论文
共 59 条
[1]   Metallic Scaffolds for Bone Regeneration [J].
Alvarez, Kelly ;
Nakajima, Hideo .
MATERIALS, 2009, 2 (03) :790-832
[2]   Non-rigid registration of multi-modal images using both mutual information and cross-correlation [J].
Andronache, A. ;
von Siebenthal, M. ;
Szekely, G. ;
Cattin, Ph. .
MEDICAL IMAGE ANALYSIS, 2008, 12 (01) :3-15
[3]   Mechanical properties of open-cell rhombic dodecahedron cellular structures [J].
Babaee, Sahab ;
Jahromi, Babak Haghpanah ;
Ajdari, Amin ;
Nayeb-Hashemi, Hamid ;
Vaziri, Ashkan .
ACTA MATERIALIA, 2012, 60 (6-7) :2873-2885
[4]   Porous NiTi for bone implants: A review [J].
Bansiddhi, A. ;
Sargeant, T. D. ;
Stupp, S. I. ;
Dunand, D. C. .
ACTA BIOMATERIALIA, 2008, 4 (04) :773-782
[5]   Shape-memory NiTi foams produced by replication of NaCl space-holders [J].
Bansiddhi, A. ;
Dunand, D. C. .
ACTA BIOMATERIALIA, 2008, 4 (06) :1996-2007
[6]  
Beckmann F., 2008, P SPIE, V7078
[7]   Three-Dimensional Ingrowth of Bone Cells Within Biodegradable Cryogel Scaffolds in Bioreactors at Different Regimes [J].
Bolgen, Nimet ;
Yang, Ying ;
Korkusuz, Peter ;
Guzel, Elif ;
El Haj, Alicia J. ;
Piskin, Erhan .
TISSUE ENGINEERING PART A, 2008, 14 (10) :1743-1750
[8]  
Bormann T., 2013, STRUCTURE THERMOMECH
[9]  
Bormann T, 2010, P SPIE, V7804
[10]   Assessing the morphology of selective laser melted NiTi-scaffolds for a three-dimensional quantification of the one-way shape memory effect [J].
Bormann, Therese ;
de Wild, Michael ;
Beckmann, Felix ;
Mueller, Bert .
BEHAVIOR AND MECHANICS OF MULTIFUNCTIONAL MATERIALS AND COMPOSITES 2013, 2013, 8689