Age and adenosine deaminase's impact on the diagnosis of pleural tuberculosis

Background: ADA levels in PF of 290 individuals were tested to investigate pleural effusion. Based on a positive pleural biopsy, each patient was assessed for age, sex, and the presence of tuberculosis (TB). The Kruskal-Wallis one-way analysis of variance was used to analyze differences in ADA levels between groups. The likelihood of TB was also predicted using logistic regression analysis. Utilizing the receiver operating characteristic (ROC) curve, ADA cut-off levels were chosen. Aims & Objective: Our study aims to establish an ADA cutoff value for the population and explore the possibility that patient variables may affect ADA. Methods & Materials: We conducted a retrospective analysis of 309 M pleural effusion patients admitted to Santosh University, Ghaziabad, between 2016 and 2018. Information was gathered from patients' medical records. Age, sex, and whether or not a pleural biopsy for TB was positive were all recorded. Results: When compared to non-tuberculous pleural patients, the mean PF ADA level was considerably higher in the tuberculous pleural group (63.3 +/- 6.29 IU/l vs. 19.6 +/- 31 IU/l, P, 0.001). Age and PF ADA levels were significantly correlated; for patients older than 745 years, the ROC curve for ADA had an area under the curve of 0.89. A 29 IU/l ADA level produced a sensitivity and specificity of 87.4% and 90.3%, respectively. Conclusion: Age and PFADA level have a substantial negative association. The quantity of false-negative outcomes is decreased by using a lower ADA cut-off.