Melatonin does not reduce anxiety more than placebo in the elderly undergoing surgery

被引：45

作者：

Capuzzo, Maurizia

Zanardi, Barbara

Schiffino, Elisa

Buccoliero, Cosimetta

Gragnaniello, Daniela

Bianchi, Stefano

Alvisi, Raffaele

机构：

[1] Univ Hosp, Dept Surg Anesthet & Radiol Sci, Sect Anesthesiol & Intens Care, Ferrara, Italy

[2] Univ Hosp, Dept Neurosci, Neurol Sect, Ferrara, Italy

来源：

ANESTHESIA AND ANALGESIA | 2006年 / 103卷 / 01期

关键词：

D O I：

10.1213/01.ane.0000222476.62547.ed

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Melatonin has been reported to reduce preoperative anxiety. We performed this study to compare preoperative anxiety in elderly patients receiving melatonin (M) or placebo (P). Anxiety was measured in patients aged > 65 yr by a numerical rating scale (range, 0-10). Each patient was randomized to receive M 10 mg or P orally: 71 patients were in group P and 67 in group M. The median (quartiles) anxiety level was 5 (2-8) before and 3 (1-7) 90 min after premedication in group M and 5 (3-6) and 3 (1-5) in group P, respectively. M and P reduce anxiety in elderly patients to a similar degree.

引用

页码：121 / 123

页数：3

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