A case of Vogt-Koyanagi-Harada-like uveitis secondary to dabrafenib/trametinib therapy for advanced melanoma

被引：13
|
作者：
Brambati, Maria [1 ]
Giuffre, Chiara [1 ]
Marchese, Alessandro [1 ]
Bandello, Francesco [1 ]
Modorati, Giulio Maria [1 ]
Miserocchi, Elisabetta [1 ]
机构：
[1] Univ Vita Salute, San Raffaele Sci Inst, Dept Ophthalmol, Milan, Italy
来源：
EUROPEAN JOURNAL OF OPHTHALMOLOGY | 2022年 / 32卷 / 01期
关键词：
Immunology; choroidal; retinal inflammation; UVEA; panuveitis; UVEITIS; systemic drug retinal toxicity; RETINA; pharmacology; MALIGNANT-MELANOMA;
D O I：
10.1177/1120672120962044
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
We report a case of ocular drug toxicity consistent with bilateral Vogt-Koyanagi-Harada (VKH) like disease in a patient with cutaneous melanoma treated with Dabrafenib/Trametinib therapy. A 53-year-old man with a history of metastatic cutaneous melanoma, treated with Dabrafenib/Trametinib, developed a severe acute panuveitis with granulomatous anterior uveitis and multiple serous retinal detachments. The ocular inflammatory reaction was classified as a bilateral Vogt-Koyanagi-Harada disease. Intraocular inflammation resolved after discontinuation of chemotherapeutic agents and aggressive topical and systemic corticosteroid therapy. The present case outlines the importance of recognizing VKH-like syndrome as a possible consequence of therapy with dabrafenib and trametinib.
引用
收藏
页码：NP109 / NP113
页数：5
相关论文
共 50 条
  • [1] Multimodal Imaging Approach in a Patient with Vogt-Koyanagi-Harada-like Syndrome Due to Dabrafenib and Trametinib Use for Cutaneous Melanoma
    Bellanca, Riccardo Francesco
    Pinna, Antonio
    Catania, Giovanna
    Belcastro, Elena
    Angi, Martina
    D'Amico Ricci, Giuseppe
    OCULAR IMMUNOLOGY AND INFLAMMATION, 2023, 31 (02) : 402 - 406
  • [2] A Case Report and Literature Review of Vogt-Koyanagi-Harada-Like Uveitis Secondary to Dabrafenib and Trametinib: 4-Year Follow-Up Using Retinal Multimodal Imaging
    Gunduz, Gamze Ucan
    Gullulu, Zeynep Zahide
    Tekcan, Sema Nizam
    Yalcinbayir, Ozgur
    Cubukcu, Erdem
    OCULAR IMMUNOLOGY AND INFLAMMATION, 2024, 32 (10) : 2589 - 2593
  • [3] Case with metastatic cutaneous malignant melanoma that developed Vogt-Koyanagi-Harada-like uveitis following pembrolizumab treatment
    Enomoto, Hiroko
    Kato, Kumiko
    Sugawara, Asako
    Itabashi, Moe
    Kondo, Mineo
    DOCUMENTA OPHTHALMOLOGICA, 2021, 142 (03) : 353 - 360
  • [4] Vogt-Koyanagi-Harada-Like Uveitis Secondary to Pembrolizumab in Metastatic Gastric Cancer: A Case Report and Review of the Literature
    Denu, Ryan A.
    Mcdermott, John J.
    Patel, Shivani C.
    Patel, Tejal
    Dahr, Sami S.
    CASE REPORTS IN ONCOLOGY, 2024, 17 (01): : 1071 - 1086
  • [5] Vogt-Koyanagi-Harada-like disease secondary to anticancer treatment: a multicentre case series
    Urzua, Cristhian A.
    Olate-Perez, Alvaro
    Anguita, Rodrigo
    Schlaen, Ariel
    Munk, Marion R.
    Carreno, Ester
    Garza-Leon, Manuel
    Sainz-de-la-Maza, Maite
    Adan, Alfredo
    Takeuchi, Masaru
    Pavesio, Carlos
    Sabat, Pablo E.
    Labbe, Eduardo
    Duarte, Gonzalo
    Couto, Cristobal
    Cuitino, Loreto
    Arellanes-Garcia, Lourdes
    Fuseau, Michelle
    Cairoli, Ernesto
    Vidal, Rodrigo
    Curi, Andre
    de-la-Torre, Alejandra
    Concha-del-Rio, Luz Elena
    EYE, 2025,
  • [6] Vogt-Koyanagi-Harada-like Syndrome Complicating Pembrolizumab Treatment for Metastatic Melanoma
    Bricout, Marion
    Petre, Adeline
    Amini-Adle, Mona
    Bezza, Widad
    Seve, Pascal
    Kodjikian, Laurent
    Dalle, Stephane
    Thomas, Luc
    JOURNAL OF IMMUNOTHERAPY, 2017, 40 (02) : 77 - 82
  • [7] A Case of Vogt-Koyanagi-Harada-like Syndrome Associated with Immunotherapy (Pembrolizumab)
    Park, Sejun
    Park, Jong Beom
    Kim, Kiyoung
    JOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY, 2023, 64 (12): : 1259 - 1262
  • [8] Vogt-Koyanagi-Harada-like Syndrome and Electronegative Electroretinogram after Nivolumab Therapy for Metastatic Cutaneous Melanoma: A Case Report
    Pole, Cameron
    Su, Erin
    Kesavamoorthy, Niranjana
    Gokoffski, Kimberly
    Sanfilippo, Christian
    Ameri, Hossein
    OPEN OPHTHALMOLOGY JOURNAL, 2023, 17
  • [9] Vogt-Koyanagi-Harada-like syndrome induced by immune checkpoint inhibitors in a patient with melanoma
    Yoshida, S.
    Shiraishi, K.
    Mito, T.
    Sayama, K.
    CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2020, 45 (07) : 908 - 911
  • [10] Vogt-Koyanagi-Harada-like findings as the first manifestation of neuroleukaemia
    Garcia, Laura Fernandez
    Fustel, Paula Boned
    Sanchez, Anselmo Feliciano
    Gil, Romana Garcia
    ACTA OPHTHALMOLOGICA, 2024, 102
12345