A New Series of Quadrupolar Type Two-Photon Absorption Chromophores Bearing 11,12-Dibutoxydibenzo[a,c]-phenazine Bridged Amines; Their Applications in Two-Photon Fluorescence Imaging and Two-Photon Photodynamic Therapy

被引：129

作者：

Velusamy, Marappan ^{[1
]}

Shen, Jiun-Yi ^{[1
]}

Lin, Jiann T. ^{[1
]}

Lin, Yi-Chih ^{[2
]}

Hsieh, Cheng-Chih ^{[2
]}

Lai, Chin-Hung ^{[2
]}

Lai, Chih-Wei ^{[2
]}

Ho, Mei-Lin ^{[2
]}

Chen, Yu-Chun ^{[2
]}

Chou, Pi-Tai ^{[2
]}

Hsiao, Jong-Kai ^{[3
]}

机构：

[1] Acad Sinica, Inst Chem, Taipei 115, Taiwan

[2] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

[3] Natl Taiwan Univ, Inst Biomed Engn, Taipei 106, Taiwan

来源：

ADVANCED FUNCTIONAL MATERIALS | 2009年 / 19卷 / 15期

关键词：

SINGLET-OXYGEN GENERATION; OPTICAL-DATA STORAGE; ABSORBING FLUORENE DERIVATIVES; CONJUGATED PORPHYRIN DIMERS; EXCITATION CROSS-SECTIONS; PHOTOSENSITIZED PRODUCTION; PI-A; 2-PHOTON-ABSORBING CHROMOPHORES; PHOTOPHYSICAL PROPERTIES; SILICA NANOPARTICLES;

D O I：

10.1002/adfm.200900125

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new series of quadrupolar type two-photon absorption (2PA) chromophores 3-9 bearing a core arylamine-[a,c]phenazine-arylamine motif are synthesized in high yields. Palladium-catalyzed Stille coupling and C-N coupling reactions are utilized to prepare target chromophores. Detailed characterization and systematic studies of these molecules, including absorption and fluorescence emission, are conducted. These compounds are found to exhibit very large 2PA cross section values, for example, similar to 7000 GM at 800 nm for 8 in toluene. Two-photon-induced fluorescence imaging is successfully demonstrated in vitro using compound-8-encapsulated silica nanoparticles with excellent bio-compatibility. In combination with the capability of both one- and two-photon singlet-oxygen sensitizations, this nanocomposite demonstrates its promising potential in dual functionality toward two-photon fluorescence imaging and two-photon photodynamic therapy.

引用

页码：2388 / 2397

页数：10

共 108 条

[1] DETERMINATION OF ABSOLUTE FLUORESCENCE QUANTUM EFFICIENCY OF QUININE BISULFATE IN AQUEOUS-MEDIUM BY OPTOACOUSTIC SPECTROMETRY [J].