Microbial Signatures as a Predictive Tool in IBD-Pearls and Pitfalls

被引：8

作者：

Waldschmitt, Nadine ^{[1
]}

Metwaly, Amira ^{[1
]}

Fischer, Sandra ^{[2
]}

Haller, Dirk ^{[1
,2
]}

机构：

[1] Tech Univ Munich, Chair Nutr & Immunol, Freising Weihenstephan, Germany

[2] Tech Univ Munich, ZIEL Inst Food & Hlth, Freising Weihenstephan, Germany

来源：

INFLAMMATORY BOWEL DISEASES | 2018年 / 24卷 / 06期

关键词：

INFLAMMATORY-BOWEL-DISEASE; CROHNS-DISEASE; GUT MICROBIOTA; SUSCEPTIBILITY LOCI; ULCERATIVE-COLITIS; INTESTINAL MICROBIOTA; PEDIATRIC-PATIENTS; FECAL MICROBIOTA; GENE-SEQUENCES; HOST;

D O I：

10.1093/ibd/izy059

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Studies of microbial signatures have improved our understanding of the role of dysbiosis in gut microbiota for the pathogenesis of inflammatory bowel disease (IBD). New technological advances such as next-generation sequencing facilitate investigations on large patient cohorts, but require methodological considerations regarding study design, sample processing, data analysis, and integration. Here, we summarize recent study approaches in microbial ecology with respect to IBD research and discuss crucial process steps for the production and integration of adequate data sets.

引用

页码：1123 / 1132

页数：10

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