Does the Addition of Abiraterone to Castration Affect the Reduction in Bone Mineral Density?

被引：5
|
作者：
Nakajima, Shiori [1 ]
Inoue, Takamitsu [1 ]
Huang, Mingguo [1 ]
Takayama, Koichiro [2 ]
Kashima, Soki [1 ]
Yamamoto, Ryohei [1 ]
Koizumi, Atsushi [1 ]
Nara, Taketoshi [1 ]
Numakura, Kazuyuki [1 ]
Saito, Mitsuru [1 ]
Narita, Shintaro [1 ]
Miura, Masatomo [3 ]
Satoh, Shigeru [4 ]
Habuchi, Tomonori [1 ]
机构：
[1] Akita Univ, Dept Urol, Grad Sch Med, Akita, Japan
[2] Municipal Yokote Hosp, Dept Urol, Akita, Japan
[3] Akita Univ Hosp, Dept Pharm, Akita, Japan
[4] Akita Univ Hosp, Ctr Kidney Dis & Transplantat, Akita, Japan
来源：
IN VIVO | 2020年 / 34卷 / 06期
关键词：
Androgen deprivation therapy; bone mineral density; osteoblasts; micro-computed tomography; bone microenvironment; RESISTANT PROSTATE-CANCER; ANDROGEN DEPRIVATION THERAPY; ACETATE; INHIBITOR; IMPACT; GROWTH; CELLS;
D O I：
10.21873/invivo.12167
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background/Aim: The in vivo effect of abiraterone on bone mineral density (BMD) in addition to androgen deprivation therapy was examined using a murine model. Materials and Methods: The mice were separated into the following groups: control, abiraterone, castration, and castration+abiraterone. The percentage change in the ratio of bone to tissue volume (BV/TV), number of osteoblasts and osteoclasts, and the serum level of bone markers were compared on day 21. Results: The BV/TV ratio of the abiraterone, castration, and castration+abiraterone groups was lower than that of the control group. However, the change in the BV/TV ratio in the castration+abiraterone group was not significantly different from that in the castration group. There was no significant difference in the serum TRAP5b level and the number of osteoclasts and osteoblasts between the castration+abiraterone and the castration groups. Conclusion: The addition of abiraterone to castration did not affect BMD in the murine model.
引用
收藏
页码：3291 / 3299
页数：9
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