Two New Sesquiterpenoids from Solanum lyratum with Cytotoxic Activities

被引：45

作者：

Ren, Yan ^{[1
]}

Shen, Li ^{[2
]}

Zhang, De-Wu ^{[1
]}

Dai, Sheng-Jun ^{[1
]}

机构：

[1] Yantai Univ, Sch Pharmaceut Sci, Yantai 264005, Peoples R China

[2] Inst Marine Drug & Food, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2009年 / 57卷 / 04期

关键词：

Solanum lyratum; Solanaceae; sesquiterpenoid; lyratol C; lyratol D; cytotoxic activity; RESISTANT; CELLS;

D O I：

10.1248/cpb.57.408

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new sesquiterpenoids, lyratol C (1) and lyratol D (2), together with two known sesquiterpenoids, dehydrovomifoliol (3) and blumenol A (4), were isolated from the whole plant of Solanum lyratum. Their structures were established by spectroscopic analyses. In vitro, the four compounds showed significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC50 values in the range 3.7-8.1 mu M.

引用

页码：408 / 410

页数：3

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