Pharmacogenetics of lithium effects on glomerular function in bipolar disorder patients under chronic lithium treatment: a pilot study

被引：7

作者：

Tsermpini, Evangelia Eirini ^{[1
]}

Zhang, Yanfei ^{[2
,3
]}

Niola, Paola ^{[4
]}

Chillotti, Caterina ^{[5
]}

Ardau, Raffaella ^{[5
]}

Bocchetta, Alberto ^{[5
]}

Patrinos, George P. ^{[1
]}

Del Zompo, Maria ^{[4
,5
]}

Severino, Giovanni ^{[4
]}

Lee, Ming Ta Michael ^{[2
,3
]}

Squassina, Alessio ^{[4
]}

机构：

[1] Univ Patras, Sch Hlth Sci, Dept Pharm, Lab Mol Biol & Immunol, Patras, Greece

[2] RIKEN, Ctr Integrat Med Sci, Lab Int Alliance Genom Res, Yokohama, Kanagawa, Japan

[3] Genom Med Inst, Geisinger Hlth Syst, Danville, PA 17822 USA

[4] Univ Cagliari, Sch Med, Dept Biomed Sci, Sect Neurosci & Clin Pharmacol, I-09042 Cagliari 6, Sp, Italy

[5] Univ Hosp Cagliari, Clin Pharmacol Unit, Cagliari, Italy

来源：

NEUROSCIENCE LETTERS | 2017年 / 638卷

关键词：

Bipolar disorder; Lithium treatment; Adverse drug reaction; Kidney; Genetic variation; Glomerular filtration rate; LONG-TERM LITHIUM; CHRONIC KIDNEY-DISEASE; FILTRATION-RATE; RENAL-FUNCTION; SURVEILLANCE; METAANALYSIS; ASSOCIATION; DAMAGE; BLOOD;

D O I：

10.1016/j.neulet.2016.12.001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Bipolar disorder (BD) is a psychiatric disease characterized by alternating episodes of mania and depression. Lithium (Li) represents the mainstay treatment for BD, although a significant proportion of patients shows insufficient or no response. Li is also associated with potentially severe side effects, including renal effects. Several studies reported that Li may induce reduction of glomerular filtration rate (GFR) in patients under long-term treatment. The biological systems and the genetic factors involved in susceptibility to Li-induced renal-side effects have been scarcely explored. The aim of our study was to test the contribution of putatively risk genetic variants in Li-induced reduction in estimated GFR (eGFR) in BD patients under long-term Li treatment. Tag SNPs, located in genes previously shown to be associated with kidney dysfunction or Li mechanism of action, were selected and genotyped in a sample of 70 BD patients of Sardinian origin. SNP rs378448, located in Acid Sensing Ion Channel Neurona-1 (ACCN1) gene, showed a significant interaction with duration of Li treatment on eGFR (F-2=3.623, p = 0.033). Our preliminary findings suggest that rs378448 could predispose BD subjects to a detrimental effect of chronic Li treatment on kidney functioning. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1 / 4

页数：4

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