Immune MAL2-practice: breast cancer immunoevasion via MHC class I degradation

被引：13

作者：

Dersh, Devin ^{[1
]}

Yewdell, Jonathan W. ^{[1
]}

机构：

[1] NIAID, Viral Dis Lab, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2021年 / 131卷 / 01期

关键词：

TRANSPORT; PROTEIN; MAL2;

D O I：

10.1172/JCI144344

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The success of tumor immunotherapy, while partial, confirms the existence and importance of tumor immunosurveillance. CD8(+) T cell recognition of tumor-specific peptides bound to MHC class I (MHC-I) molecules is central to this process. In this issue of the JCI, Fang, Wang, et al. describe a unique tumor immunoevasion strategy based on endocytosis and degradation of MHC-I complexes mediated by the trafficking factor MAL2. Notably, MAL2 expression was associated with poor prognosis of breast cancer, and its downregulation enhanced CD8(+) T cell recognition of breast cancer in various experimental models. This work demonstrates that a deeper understanding of tumor interference with MHC-I stability and trafficking has considerable potential for enhancing immunotherapies.

引用

页数：4

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