Cyclodepsipeptides from the ascocarps and insect-body portions of fungus Cordyceps cicadae

被引：32

作者：

Wang, Jing ^{[1
]}

Zhang, Dong-Mei ^{[1
]}

Jia, Jun-Feng ^{[1
]}

Peng, Qun-Long ^{[1
]}

Tian, Hai-Yan ^{[1
]}

Wang, Lei ^{[1
,2
]}

Ye, Wen-Cai ^{[1
,2
]}

机构：

[1] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

[2] Jinan Univ, JNU HKUST Joint Lab Neurosci & Innovat Drug Res, Guangzhou 510632, Guangdong, Peoples R China

来源：

FITOTERAPIA | 2014年 / 97卷

基金：

中国国家自然科学基金;

关键词：

Cyclodepsipeptides; Clavicipitaceae; Cordyceps cicadae; Cytotoxic activities;

D O I：

10.1016/j.fitote.2014.05.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new cyclodepsipeptide cordycecin A (1), together with four known ones beauvericin E (2), beauvericin J (3), beauvericin (4), and beauvericin A (5) was isolated from the ascocarps and insect-body portions of fungus Cordyceps cicadae. Their structures were identified by NMR and MS analyses. The absolute configuration of 1 was confirmed by crystal X-ray diffraction. Compounds 2-5 exhibited a significant inhibitory effect on HepG2 and HepG2/ADM cells with IC50 values ranging from 2.40 +/- 0.37 to 14.48 +/- 1.68 pM. Interestingly, compounds 3-5 showed cytotoxic activity against multiple drug resistant HepG2 cell line (HepG2/ADM) with IC50 value 25-fold more sensitive to doxorubicin. (c) 2014 Elsevier B.V. All rights reserved.

引用

页码：23 / 27

页数：5

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