Cytotoxic effects of flavonoids against a human colon cancer derived cell line, COLO 201: A potential natural anti-cancer substance

被引：55

作者：

Imai, Masahiko ^{[1
]}

Kikuchi, Hidetomo ^{[1
]}

Denda, Takanori ^{[1
]}

Ohyama, Kunio ^{[1
]}

Hirobe, Chieko ^{[2
]}

Toyoda, Hiroo ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Dept Clin Mol Genet, Sch Pharm, Tokyo 1920392, Japan

[2] Seisen Univ, Dept Cultural Hist, Shinagawa Ku, Tokyo 1410022, Japan

来源：

CANCER LETTERS | 2009年 / 276卷 / 01期

关键词：

Colon cancer; Apoptosis induction; Flavonoids; Natural products; VITEX-AGNUS-CASTUS; HUMAN FETAL MEMBRANE; HEME OXYGENASE-1; FRUIT EXTRACT; PREMENSTRUAL-SYNDROME; COLORECTAL-CANCER; IN-VITRO; APOPTOSIS; GROWTH; INCUBATION;

D O I：

10.1016/j.canlet.2008.10.036

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The proliferation of a human colon carcinoma cell line, COLO 201, was effectively suppressed through apoptosis in the presence of flavonoids, an ethanol extract from Vitex agnus-castus fruits. The induction of apoptosis was not inhibited by the presence of an anti-oxidant, N-acetyl-L-cysteine, whereas only HO-1 gene expression levels increased among other typical oxidative stress-associated genes examined after Vitex treatment. These results suggest that Vitex treatment activates a pathway associated with HO-1 gene activation, resulting in the induction of apoptosis in COLO 201. Results also implicate a potential clinical chemotherapeutic application of Vitex for the treatment of colon cancer patients. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：74 / 80

页数：7

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