The Role of Ubiquitination and Sumoylation in Diabetic Nephropathy

被引：34
|
作者：
Gao, Chenlin [1 ]
Huang, Wei [1 ]
Kanasaki, Keizo [2 ]
Xu, Yong [1 ]
机构：
[1] Luzhou Med Coll, Affiliated Hosp, Dept Endocrinol, Luzhou 646000, Sichuan, Peoples R China
[2] Kanazawa Med Univ, Div Diabetol & Endocrinol, Uchinada, Ishikawa 9200293, Japan
来源：
BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷
基金：
日本学术振兴会;
关键词：
NF-KAPPA-B; HIGH GLUCOSE; TRANSCRIPTION FACTOR; PROTEASOME SYSTEM; BETA RECEPTOR; UP-REGULATION; PROTEIN; SUMO; ACTIVATION; EXPRESSION;
D O I：
10.1155/2014/160692
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Diabetic nephropathy (DN) is a common and characteristic microvascular complication of diabetes; the mechanisms that cause DN have not been clarified, and the epigenetic mechanism was promised in the pathology of DN. Furthermore, ubiquitination and small ubiquitin-like modifier (SUMO) were involved in the progression of DN. MG132, as a ubiquitin proteasome, could improve renal injury by regulating several signaling pathways, such as NF-kappa B, TGF-beta, Nrf2-oxidative stress, and MAPK. In this review, we summarize how ubiquitination and sumoylation may contribute to the pathology of DN, which may be a potential treatment strategy of DN.
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收藏
页数：11
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