Effects of Gender on the Association of Urinary Phthalate Metabolites with Thyroid Hormones in Children: A Prospective Cohort Study in Taiwan

被引：48

作者：

Weng, Te-I ^{[1
,2
,3
,4
]}

Chen, Mei-Huei ^{[5
]}

Lien, Guang-Wen ^{[5
]}

Chen, Pai-Shan ^{[1
,2
,3
]}

Lin, Jasper Chia-Cheng ^{[4
]}

Fang, Cheng-Chung ^{[2
,3
,4
]}

Chen, Pau-Chung ^{[5
,6
,7
,8
]}

机构：

[1] Natl Taiwan Univ, Inst Forens Med, Coll Med, Taipei 10051, Taiwan

[2] Natl Taiwan Univ, Forens & Clin Toxicol Ctr, Coll Med, Taipei 10051, Taiwan

[3] Natl Taiwan Univ Hosp, Taipei 10051, Taiwan

[4] Natl Taiwan Univ Hosp, Dept Emergency Med, Taipei 10002, Taiwan

[5] Natl Taiwan Univ, Inst Occupat Med & Ind Hyg, Coll Publ Hlth, Taipei 10055, Taiwan

[6] Natl Taiwan Univ, Dept Environm & Occupat Med, Coll Med, Taipei 10051, Taiwan

[7] Natl Taiwan Univ Hosp, Taipei 10051, Taiwan

[8] Natl Taiwan Univ, Dept Publ Hlth, Coll Publ Hlth, Taipei 10055, Taiwan

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2017年 / 14卷 / 02期

关键词：

phthalates; thyroid hormones; children; gender; BISPHENOL-A; EXPOSURE; PLASTICIZERS; HEALTH; BLOOD; DEHP;

D O I：

10.3390/ijerph14020123

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Phthalates are considered endocrine disruptors. Our study assessed the gender-specific effects of phthalate exposure on thyroid function in children. In total, 189 Taiwanese children were enrolled in the study. One-spot urine and blood samples were collected for analyzing 12 phthalate metabolites in urine and thyroid hormones. The association between urinary phthalate metabolites and serum thyroid hormones was determined using a generalized linear model with a log link function; the children were categorized into groups for analysis according to the 33rd and 66th percentiles. The data were stratified according to gender and adjusted for a priori defined covariates. In girls, a positive association existed between urinary di-2-ethylhexyl phthalate (DEHP) metabolites (mono-(2-ethylhexyl) phthalate, mono-(2-ethyl-5-oxohexyl) phthalate, and mono-(2-ethyl-5-hydroxyhexyl) phthalate) and free thyroxine (T4). In boys, urinary dibutyl phthalate (DBP) metabolites (mono-i-butyl phthalate and mono-n-butyl phthalate) were positively associated with free triiodothyronine (T3). After categorizing each exposure into three groups, urinary DEHP metabolites were positively associated with free T3 levels in boys. Our results suggested that DEHP is associated with free T4 in girls and that DBP is associated with free T3 in boys. Higher DEHP metabolite concentrations exerted larger effects on free T3 in boys. These results reveal the gender-specific relationships between phthalate metabolites and thyroid hormones.

引用

页数：23

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