Preparation, characterization, molecular modeling and in vitro activity of paclitaxel-cyclodextrin complexes

被引：50

作者：

Alcaro, S

Ventura, CA

Paolino, D

Battaglia, D

Ortuso, F

Cattel, L

Puglisi, G

Fresta, M

机构：

[1] Univ Magna Graecia Catanzaro, Dept Pharmacobiol Sci, I-88021 Roccelletta Di Borgia, CZ, Italy

[2] Univ Messina, Dept Pharmacochem, I-98168 Messina, Italy

[3] Univ Catania, Dept Pharmaceut Sci, I-95125 Catania, Italy

[4] Univ Turin, Dept Drug Sci & Technol, I-10125 Turin, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(02)00217-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Paclitaxel (PTX) was complexed with beta-cyclodextrin (1), 2,6-dimethyl-beta-cyclodextrin (2) and 2,3,6-trimethyl-beta-cyclodextrin (3). PTX-CYD complexes were characterized both at the solid and liquid states. Experimental findings are in agreement, with molecular modeling analysis, which showed different PTX-CYD interaction as a function of macrocyle methylation. The complexation of PTX within the CYD cavity preserved its antitumoral activity. (C) 2002 Published by Elsevier Science Ltd.

引用

页码：1637 / 1641

页数：5

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