A computer simulation of in vivo tumour growth and response to radiotherapy: New algorithms and parametric results

被引：25

作者：

Dionysiou, DD ^{[1
]}

Stamatakos, GS ^{[1
]}

Uzunoglu, NK ^{[1
]}

Nikita, KS ^{[1
]}

机构：

[1] Natl Tech Univ Athens, Sch Elect & Comp Engn, Div Informat Transmiss Syst & Mat Technol, GR-15780 Zografos, Greece

来源：

COMPUTERS IN BIOLOGY AND MEDICINE | 2006年 / 36卷 / 05期

关键词：

modelling; tumour; cancer; radiotherapy; visualization; simulation;

D O I：

10.1016/j.compbiomed.2005.02.003

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The aim of this paper is to present the newest algorithms and simulation results of a computer model of in vivo tumour growth and response to radiotherapy. The new algorithms are analytically presented. A set of parametric simulations has been performed with special emphasis on the influence of the genetic profile of a tumour on its radiosensitivity. The results of the simulation procedure are three-dimensionally visualized and critically surveyed. The long-term goal of this work is twofold: the development of a computational tool for getting insight into cancer biology and the development of a patient-specific decision support system. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：448 / 464

页数：17

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