A computer simulation of in vivo tumour growth and response to radiotherapy: New algorithms and parametric results

被引：25
作者：
Dionysiou, DD [1 ]
Stamatakos, GS [1 ]
Uzunoglu, NK [1 ]
Nikita, KS [1 ]
机构：
[1] Natl Tech Univ Athens, Sch Elect & Comp Engn, Div Informat Transmiss Syst & Mat Technol, GR-15780 Zografos, Greece
来源：
COMPUTERS IN BIOLOGY AND MEDICINE | 2006年 / 36卷 / 05期
关键词：
modelling; tumour; cancer; radiotherapy; visualization; simulation;
D O I：
10.1016/j.compbiomed.2005.02.003
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The aim of this paper is to present the newest algorithms and simulation results of a computer model of in vivo tumour growth and response to radiotherapy. The new algorithms are analytically presented. A set of parametric simulations has been performed with special emphasis on the influence of the genetic profile of a tumour on its radiosensitivity. The results of the simulation procedure are three-dimensionally visualized and critically surveyed. The long-term goal of this work is twofold: the development of a computational tool for getting insight into cancer biology and the development of a patient-specific decision support system. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：448 / 464
页数：17
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