The dynamic personality of TATA-binding protein

被引：20
|
作者：
Auble, David T. [1 ]
机构：
[1] Univ Virginia Hlth Syst, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2009年 / 34卷 / 02期
关键词：
POLYMERASE-II TRANSCRIPTION; SACCHAROMYCES-CEREVISIAE; GENE-EXPRESSION; CORE PROMOTERS; IN-VIVO; MOT1; NC2; TBP; COMPLEX; SPT3;
D O I：
10.1016/j.tibs.2008.10.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
TATA-binding protein (TBP) is a central component of the transcription apparatus and its association with promoters is dynamically regulated genome-wide. Recent work has shed new light on the functional specificity of Mot1 and NC2, two factors that control TBP distribution and activity. These studies underscore how regulation of TBP globally influences fundamental aspects of gene expression, including the balance of transcriptional output from different types of promoters, and the amplitude and timing of gene activation.
引用
收藏
页码：49 / 52
页数：4
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