Recent evidence suggests that: passenger leukocytes migrate after organ transplantation and produce persistent chimerism, which is essential for sustained survival of the allograft, Here, we describe how this hematolymphopoietic chimerism provides an important framework for interpretation of post-transplant phenomena and for initiation of therapeutically oriented transplantation research.
机构:
Univ Calif San Diego, Div Clin Pharm, Skaggs Sch Pharm & Pharmaceut Sci, 9500 Gilman Dr, La Jolla, CA 92093 USAUniv Calif San Diego, Div Clin Pharm, Skaggs Sch Pharm & Pharmaceut Sci, 9500 Gilman Dr, La Jolla, CA 92093 USA