Self-amplified depolymerization of oligo(thiourethanes) for the release of COS/H2S

被引：0

作者：

Powell, Chadwick R. ^{[1
]}

Foster, Jeffrey C. ^{[1
]}

Swilley, Sarah N. ^{[1
]}

Kaur, Kuljeet ^{[1
]}

Scannelli, Samantha J. ^{[1
]}

Troya, Diego ^{[1
]}

Matson, John B. ^{[1
]}

机构：

[1] Virginia Tech, Ctr Drug Discovery, Macromol Innovat Inst, Dept Chem, 1040 Drillfield Dr, Blacksburg, VA 24061 USA

来源：

POLYMER CHEMISTRY | 2019年 / 10卷 / 23期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

HYDROGEN-SULFIDE; H2S DONORS; DELIVERY; PATHOGENESIS; DENDRIMERS; MOLECULE; DONATION; DESIGN; COS;

D O I：

10.1039/c9py00354a

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Herein we report the self-amplified depolymerization of an aryl oligo(thiourethane) (OTU) for the release of COS/H2S. The OTU was synthesized via polyaddition of 4-isothiocyanatobenzyl alcohol and end-capped with an aryl azide. The aryl azide chain-end was reduced by tris(2-carboxyethyl)phosphine or H2S to the corresponding aniline, resulting in depolymerization (i.e., self-immolation) and the release of COS/H2S. Depolymerization was monitored by H-1 NMR and UV-Vis spectroscopy, and the released COS was converted into H2S by the ubiquitous enzyme carbonic anhydrase in aqueous media, generating an amplified response.

引用

页码：2991 / 2995

页数：5

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