The significance of bone marrow cell morphology and its correlation with cytogenetic features in the diagnosis of MDS-RA patients

被引：17

作者：

Liu, Dandan ^{[1
]}

Chen, Zixing ^{[1
]}

Xue, Yongquan ^{[1
]}

Lu, Dingwei ^{[1
]}

Zhou, Youning ^{[1
]}

Gong, Jingxia ^{[1
]}

Wu, Weilin ^{[1
]}

Liang, Jianying ^{[1
]}

Ma, Qinfen ^{[1
]}

Pan, Jinlan ^{[1
]}

Wu, Yafang ^{[1
]}

Wang, Yong ^{[1
]}

Zhang, Jun ^{[1
]}

Shen, Juan ^{[1
]}

机构：

[1] Soochow Univ, Affiliated Hosp 1, Leukemia Res Div,Minist Hlth, Jiangsu Inst Hematol,Key Lab Thrombosis & Hemosta, Suzhou 215006, Peoples R China

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 08期

关键词：

MDS; Dysplasia; Cytogenetical abnormality; Diagnosis; MYELODYSPLASTIC SYNDROME; CLASSIFICATION; PROPOSALS;

D O I：

10.1016/j.leukres.2009.02.011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Besides cytopenia, dysplasia is crucial characteristic of MDS-RA. To summarize the morphological features that contribute to the diagnosis of MDS-RA, 48 RA patients with abnormal karyotype were analyzed for the features of morphological and cytogenetical abnormalities and the relationships between them. 46 MDS-RA patients with normal karyotype and 207 patients with non-MDS anemia were enrolled into control groups. More conspicuous and diverse dysplasia can be found in abnormal karyotype MDS-RA than those in control groups (P<0.05). Apparent dysplasia in granulocyte and megakaryocytoid lineages may provide valuable evidence for the diagnosis. Dysplasia occurred more frequently in patients with severe chromosome abnormalities. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1029 / 1038

页数：10

共 20 条

[1] Bone marrow morphology and classification systems in myelodysplastic syndromes [J].

Aul, Carlo ;

GiagounidiS, Aristoteles ;

Germing, Ulrich .

CANCER TREATMENT REVIEWS, 2007, 33 :S2-S5

[2]

Bando S, 1998, Rinsho Byori, V46, P790

[3] PROPOSALS FOR THE CLASSIFICATION OF THE MYELODYSPLASTIC SYNDROMES [J].

BENNETT, JM ;

CATOVSKY, D ;

DANIEL, MT ;

FLANDRIN, G ;

GALTON, DAG ;

GRALNICK, HR ;

SULTAN, C .

BRITISH JOURNAL OF HAEMATOLOGY, 1982, 51 (02) :189-199

[4] Narrowing and genomic annotation of the commonly deleted region of the 5q-syndrome [J].

Boultwood, J ;

Fidler, C ;

Strickson, AJ ;

Watkins, F ;

Gama, S ;

Kearney, L ;

Tosi, S ;

Kasprzyk, A ;

Cheng, JF ;

Jaju, RJ ;

Wainscoat, JS .

BLOOD, 2002, 99 (12) :4638-4641

[5] Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries [J].

Chen, B ;

Zhao, WL ;

Jin, J ;

Xue, YQ ;

Cheng, X ;

Chen, XT ;

Cui, J ;

Chen, ZM ;

Cao, Q ;

Yang, G ;

Yao, Y ;

Xia, HL ;

Tong, JH ;

Li, JM ;

Chen, J ;

Xiong, SM ;

Shen, ZX ;

Waxman, S ;

Chen, Z ;

Chen, SJ .

LEUKEMIA, 2005, 19 (05) :767-775

[6]

Font P, 2007, BLOOD, V110, p728A

[7] Molecular mechanisms of myelodysplastic syndrome [J].

Hirai, H .

JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2003, 33 (04) :153-160

[8]

JAFFE ES, 2001, PATHOLOGY GENETICS T, P61

[9]

KOBAYASHI Y, 1995, INT J HEMATOL, V61, P117

[10]

Miguel Amparo, 2007, Lab Hematol, V13, P98, DOI 10.1532/LH96.07011

← 1 2 →