3D Long-Range Triplet Migration in a Water-Stable Metal-Organic Framework for Upconversion-Based Ultralow-Power in Vivo Imaging

被引：174

作者：

Park, Jihye ^{[1
,4
]}

Xu, Ming ^{[2
,3
]}

Li, Fuyou ^{[2
,3
]}

Zhou, Hong-Cai ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA

[2] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

[3] Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China

[4] Stanford Univ, Dept Chem Engn, Stanford, CA 94305 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 140卷 / 16期

基金：

中国国家自然科学基金;

关键词：

ENERGY MIGRATION; LIGAND COORDINATION; AQUEOUS-PHASE; ANNIHILATION; NANOPARTICLES; CANCER; PHOTOCATALYSIS; NANOCAPSULES; EMISSION; DYNAMICS;

D O I：

10.1021/jacs.8b01613

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Triplet-triplet annihilation upconversion (TTA-UC) has gained increasing attention because it allows for harvesting of low-energy photons in the solar spectrum with high efficiency in relevant applications including solar cells and bioimaging. However, the utilization of conventional TTA-UC systems for low-power bioapplications is significantly hampered by their general incompatibility and low efficiency in aqueous media. Herein we report a metal-organic framework (MOF) as a biocompatible nanoplatform for TTA-UC to realize low-power in vivo imaging. Our MOF consists of a porphyrinic sensitizer in an anthracene-based Zr-MOF as a TTA-UC platform. In particular, closely aligned chromophores in the MOF facilitate a long-range 3D triplet diffusion of 1.6 mu m allowing efficient energy migration in water. The tunable ratio between sensitizer and annihilator by our synthetic method also allows an optimization of the system for maximized TTA-UC efficiency in water at a very low excitation power density. Consequently, the low-power imaging of lymph node in a live mouse was successfully demonstrated with an excellent signal-to-noise ratio (SNR > 30 at 5 mW cm(-2)).

引用

页码：5493 / 5499

页数：7

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