Combined Exercise Training Improves Glycemic Control in Adult with Cystic Fibrosis

Purpose: Glucose abnormality and diabetes are the most common comorbidities in cystic fibrosis (CF). Combined (aerobic and resistance) exercise program in type 2 patients with diabetes demonstrated an improvement of glycemic control. The aim of the study was to determine whether a combined exercise program is beneficial to improve plasma glucose at 2 h of the oral glucose tolerance test in CF. Method: Eighteen adults with CF with glucose abnormality were recruited (Clinicaltrial.gov: NTC02127957), and 17 were randomly assigned to a control or exercise group for 12 wk. (V) over dotO(2max), oral glucose tolerance test, muscular endurance and strength, and quality of life were measured pre- and postintervention. Results: Fourteen participants completed the protocol. Patients in the exercise group improved significantly their 2-h plasma glucose values (-2.34 +/- 1.26 mmol.L-1, P < 0.007, confidence interval = 99.22%) and presented a reduction of 17.2% (P < 0.05) in total glucose excursion. No significant change for other parameters was observed. Conclusion: A combined exercise program improves glycemic control in CF.