Beyond apoptosis of JNK1 in liver cancer

被引：19

作者：

Chen, Fei ^{[1
]}

Castranova, Vince ^{[1
]}

机构：

[1] NIOSH, Hlth Effects Lab Div, Pathol & Physiol Res Branch, Morgantown, WV USA

来源：

CELL CYCLE | 2009年 / 8卷 / 08期

关键词：

JNK1; HCC; apoptosis; epigenetics; HEPATOCELLULAR-CARCINOMA; GENE POLYMORPHISMS; VIRUS-INFECTION; PROLIFERATION; KINASES; CELLS;

D O I：

10.4161/cc.8.8.8200

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hepatocellular Carcinoma (HCC) is the fourth most common neoplasm and the third leading cause of cancer-related death worldwide. Tremendous effort has been made during the past several years in understanding the molecular mechanisms governing the pathogenesis and progression of HCC. Recent studies indicated that c-Jun N-terminal kinase 1 (JNK1), but not JNK2, played pivotal role in the expression of the key signature genes and the prognostic outcomes of HCC. Accordingly, we believe that targeting JNK1 is not only mechanistically sound but also clinically feasible for the treatment of HCC.

引用

页码：1145 / 1147

页数：3

共 15 条

[1] The functional contrariety of JNK [J].

Bode, Ann M. ;

Dong, Zigang .

MOLECULAR CARCINOGENESIS, 2007, 46 (08) :591-598

[2] Sustained JNK1 activation is associated with altered histone H3 methylations in human liver cancer [J].

Chang, Qingshan ;

Zhang, Yadong ;

Beezhold, Kevin J. ;

Bhatia, Deepak ;

Zhao, Hongwen ;

Chen, Jianguo ;

Castranova, Vince ;

Shi, Xianglin ;

Chen, Fei .

JOURNAL OF HEPATOLOGY, 2009, 50 (02) :323-333

[3]

Chen F., 2003, Atlas Genet. Cytogenet. Oncol

[4] Signal transduction by the JNK group of MAP kinases [J].

Davis, RJ .

CELL, 2000, 103 (02) :239-252

[5] JNK signaling in apoptosis [J].

Dhanasekaran, D. N. ;

Reddy, E. P. .

ONCOGENE, 2008, 27 (48) :6245-6251

[6] Myc represses the p21(WAF1/CIP1) promoter and interacts with Sp1/Sp3 [J].

Gartel, AL ;

Ye, X ;

Goufman, E ;

Shianov, P ;

Hay, N ;

Najmabadi, F ;

Tyner, AL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (08) :4510-4515

[7] Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation [J].

Hui, Lijian ;

Zatloukal, Kurt ;

Scheuch, Harald ;

Stepniak, Ewa ;

Wagner, Erwin F. .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (12) :3943-3953

[8] From JNK to pay dirt: Jun kinases, their biochemistry, physiology and clinical importance [J].

Karin, M ;

Gallagher, E .

IUBMB LIFE, 2005, 57 (4-5) :283-295

[9] Molecular targeted therapies in hepatocellular carcinoma [J].

Llovet, Josep M. ;

Bruix, Jordi .

HEPATOLOGY, 2008, 48 (04) :1312-1327

[10] Deletion of NEMO/IKKγ in liver parenchymal cells causes steatohepatitis and hepatocellular carcinoma [J].

Luedde, Tom ;

Beraza, Naiara ;

Kotsikoris, Vasileios ;

van Loo, Geert ;

Nenci, Arianna ;

De Vos, Rita ;

Roskams, Tania ;

Trautwein, Christian ;

Pasparakis, Manolis .

CANCER CELL, 2007, 11 (02) :119-132

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