Treatment of Intracerebral Hemorrhage Associated with New Oral Anticoagulant Use The Neurologist's View

被引：14
|
作者：
Veltkamp, Roland [1 ,2 ]
Horstmann, Solveig [2 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Charing Cross Hosp, Dept Stroke Med, London W6 8RF, England
[2] Heidelberg Univ, Dept Neurol, D-69120 Heidelberg, Germany
来源：
CLINICS IN LABORATORY MEDICINE | 2014年 / 34卷 / 03期
关键词：
Intracerebral hemorrhage; Warfarin; Oral anticoagulation; New oral anticoagulants; PROTHROMBIN COMPLEX CONCENTRATE; ATRIAL-FIBRILLATION; RISK-FACTORS; INTRACRANIAL HEMORRHAGE; ANTITHROMBOTIC THERAPY; HEMATOMA EXPANSION; HEMOSTATIC THERAPY; STROKE PREVENTION; PRACTICAL GUIDE; WARFARIN;
D O I：
10.1016/j.cll.2014.06.007
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Intracerebral hemorrhage (ICH) associated with the use of oral anticoagulants (OAC-ICH) results in particularly severe strokes. A key target for the treatment of OAC-ICH is rapid restoration of effective coagulation. In patients receiving vitamin K antagonists, hemostatic factors such as prothrombin complex concentrate (PCC), fresh frozen plasma, and recombinant activated factor VII, in addition to vitamin K, can be used for anticoagulation reversal. However, emergency management of ICH during treatment with the new direct OACs (NOACs) is a major challenge. In the absence of specific antidotes, PCCs are recommended for NOAC reversal, mainly based on preclinical data.
引用
收藏
页码：587 / +
页数：9
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