Acute myeloid leukemia and diabetes insipidus with monosomy 7

被引：16

作者：

Harb, Antoine ^{[1
]}

Tan, Wei ^{[2
]}

Wilding, Gregory E. ^{[2
]}

Battiwalla, Mincio ^{[3
]}

Sait, Shella N. J. ^{[4
]}

Wang, Eunice S. ^{[1
,5
]}

Wetzler, Meir ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Dept Med, Leukemia Sect, Buffalo, NY 14263 USA

[2] Roswell Pk Canc Inst, Dept Biostat, Buffalo, NY 14263 USA

[3] Roswell Pk Canc Inst, Dept Med, Blood & Marrow Transplantat Sect, Buffalo, NY 14263 USA

[4] Roswell Pk Canc Inst, Clin Cytogenet Lab, Buffalo, NY 14263 USA

[5] SUNY Buffalo, Sch Med & Biomed Sci, Dept Med, Buffalo, NY 14260 USA

来源：

CANCER GENETICS AND CYTOGENETICS | 2009年 / 190卷 / 02期

关键词：

ACUTE MYELOBLASTIC-LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; STEM-CELL TRANSPLANTATION; HIGH PLATELET COUNT; CYTOGENETIC ABNORMALITIES; MYELODYSPLASTIC SYNDROME; 3Q21Q26; SYNDROME; EVI-1; GENE; AML; ASSOCIATION;

D O I：

10.1016/j.cancergencyto.2009.01.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The predisposition of monosomy 7 to diabetes insipidus (DI) in acute myeloid leukemia (AML) led us to ask whether AML associated with monosomy 7 and DI will differ from AML associated with other karyotype aberrations and DI and whether the outcome of patients with AML and DI will differ from those without DI. We describe 2 patients from Roswell Park Cancer Institute and discuss 29 additional cases from the literature. AML with monosomy 7 and DI (n = 25) had a trend towards a lower complete remission (p = 0.0936) and worse survival (p = 0.0480) than AML with other karyotype changes and DI (n = 6). Further, AML with monosomy 7 and DI had worse complete remission rate Mid overall survival than AML with monosomy 7 but without DI. In conclusion, it appears that AML with monosomy 7 and DI is a disease entity with specifically poor outcome. (c) 2009 Elsevier Inc. All rights reserved.

引用

页码：97 / 100

页数：4

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