Prediction by Pharmacogenetics of Safety and Efficacy of Non-Steroidal Anti-Inflammatory Drugs: A Review

被引：29

作者：

Rollason, Victoria ^{[1
]}

Samer, Caroline Flora ^{[1
,2
]}

Daali, Youssef ^{[1
,2
]}

Desmeules, Jules Alexandre ^{[1
,2
]}

机构：

[1] Univ Hosp Geneva, Div Clin Pharmacol & Toxicol, Ctr Multidisciplinary Pain, CH-1211 Geneva 14, Switzerland

[2] Univ Geneva, Swiss Ctr Appl Human Toxicol, CH-1211 Geneva 4, Switzerland

来源：

CURRENT DRUG METABOLISM | 2014年 / 15卷 / 03期

关键词：

COX; CYP2C8; CYP2C9; genetic polymorphism; NSAIDs; PTGS; UDP glucuronsyltransferases; UGT; UDP-GLUCURONOSYLTRANSFERASE; 2B7; COLORECTAL ADENOMA RECURRENCE; CYTOCHROME P4502C9 GENOTYPE; HUMAN LIVER-MICROSOMES; GENETIC POLYMORPHISMS; NSAID USE; CYP2C9; GENOTYPES; MULTIDRUG-RESISTANCE; PEPTIC-ULCER; CYCLOOXYGENASE POLYMORPHISMS;

D O I：

10.2174/1389200215666140202214454

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most frequently used drugs, either on prescription or over-the-counter (OTC). Their daily dosage is based on randomised controlled trials and an empirical clinical assessment of their efficacy and toxicity that allows dose adjustment. The individual response can however be altered by environmental and genetic pharmacokinetic and pharmacodynamic factors. This review summarizes the available pharmacogenetic data that explains part of the variability in response and occurrence of adverse drug reactions to NSAIDs treatment, with a thorough focus on CYP2C9, uridine diphosphate glucuronosyl-transferases (UGTs) and cyclooxygenases (COX1 and COX2). Other polymorphisms that are currently being studied and could also explain the interindividual variability in the efficacy and safety of NSAIDs will also be considered.

引用

页码：326 / 343

页数：18

共 160 条

[41] Nonsteroidal anti inflammatory drugs, cyclooxygenase polymorphisms, and the risk of developing breast carcinoma among women with benign breast disease [J].