Bone Formation in Psoriatic Arthritis: A Report from the GRAPPA 2013 Annual Meeting

被引：14
作者：
Schett, Georg [1 ]
机构：
[1] Univ Erlangen Nurnberg, Dept Internal Med 3, D-91054 Erlangen, Germany
来源：
JOURNAL OF RHEUMATOLOGY | 2014年 / 41卷 / 06期
关键词：
PSORIATIC ARTHRITIS; PSORIASIS; BONE DESTRUCTION; BONE FORMATION; ENTHESES; CYTOKINES; PROGRESSION;
D O I：
10.3899/jrheum.140173
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The simultaneous presence of bone erosions and bony spurs (osteophytes, enthesophytes) in the joints of patients with psoriatic arthritis (PsA) suggests that the disease leads to enhanced bone resorption as well as increased bone formation, the latter of which has not been observed in patients with rheumatoid arthritis. At the 2013 Annual Meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), members heard an update on the current research into the cytokine signature in PsA and its effects on new bone formation.
引用
收藏
页码：1218 / 1219
页数：2
相关论文
共 12 条
  • [1] Benjamin M, 2009, ADV EXP MED BIOL, V649, P57
  • [2] Dickkopf-1 is a master regulator of joint remodeling
    Diarra, Danielle
    Stolina, Marina
    Polzer, Karin
    Zwerina, Jochen
    Ominsky, Michael S.
    Dwyer, Denise
    Korb, Adelheid
    Smolen, Josef
    Hoffmann, Markus
    Scheinecker, Clemens
    van der Heide, Desiree
    Landewe, Robert
    Lacey, Dave
    Richards, William G.
    Schett, Georg
    [J]. NATURE MEDICINE, 2007, 13 (02) : 156 - 163
  • [3] A comparative study of periarticular bone lesions in rheumatoid arthritis and psoriatic arthritis
    Finzel, Stephanie
    Englbrecht, Matthias
    Engelke, Klaus
    Stach, Christian
    Schett, Georg
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2011, 70 (01) : 122 - 127
  • [4] GLADMAN DD, 1990, J RHEUMATOL, V17, P809
  • [5] The infliximab multinational psoriatic arthritis controlled trial (IMPACT): results of radiographic analyses after 1 year
    Kavanaugh, A.
    Antoni, C. E.
    Gladman, D.
    Wassenberg, S.
    Zhou, B.
    Beutler, A.
    Keenan, G.
    Burmester, G.
    Furst, D. E.
    Weisman, M. H.
    Kalden, J. R.
    Smolen, J.
    van der Heijde, D.
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2006, 65 (08) : 1038 - 1043
  • [6] Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis
    Lories, RJU
    Derese, I
    Luyten, FP
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (06) : 1571 - 1579
  • [7] Mease PJ, 2006, J RHEUMATOL, V33, P712
  • [8] Mechanisms of TNF-α- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis
    Ritchlin, CT
    Haas-Smith, SA
    Li, P
    Hicks, DG
    Schwarz, EM
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2003, 111 (06) : 821 - 831
  • [9] Blockade of the hedgehog pathway inhibits osteophyte formation in arthritis
    Ruiz-Heiland, Gisela
    Horn, Angelika
    Zerr, Pawel
    Hofstetter, Willy
    Baum, Wolfgang
    Stock, Michael
    Distler, Joerg H.
    Nimmerjahn, Falk
    Schett, Georg
    Zwerina, Jochen
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2012, 71 (03) : 400 - 407
  • [10] Schett G, 2013, NAT MED, V19, P822, DOI 10.1038/nm.3260
12