Computational evaluation of amplitude modulation for enhanced magnetic nanoparticle hyperthermia

被引：27

作者：

Soetaert, Frederik ^{[1
,2
]}

Dupre, Luc ^{[1
]}

Ivkov, Robert ^{[2
,3
,4
,5
,6
]}

Crevecoeur, Guillaume ^{[1
]}

机构：

[1] Univ Ghent, Dept Elect Energy Syst & Automat, B-9052 Zwijnaarde, Belgium

[2] Johns Hopkins Univ, Dept Radiat Oncol & Mol Radiat Sci, Sch Med, Baltimore, MD 21231 USA

[3] NIST, NIST Ctr Neutron Res, Gaithersburg, MD 20899 USA

[4] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21231 USA

[5] Johns Hopkins Univ, Inst NanoBioTechnol, Baltimore, MD 21218 USA

[6] Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA

来源：

BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK | 2015年 / 60卷 / 05期

关键词：

bioheat transfer; biomagnetism; finite elements; simulation; thermal damage; thermal medicine; CANCER-THERAPY; THERMAL DOSIMETRY; BASIC PRINCIPLES; MODELS; FIELD; RELAXATION; ABLATION; DAMAGE; MOUSE; FLUID;

D O I：

10.1515/bmt-2015-0046

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Magnetic nanoparticles (MNPs) can interact with alternating magnetic fields (AMFs) to deposit localized energy for hyperthermia treatment of cancer. Hyperthermia is useful in the context of multimodality treatments with radiation or chemotherapy to enhance disease control without increased toxicity. The unique attributes of heat deposition and transfer with MNPs have generated considerable attention and have been the focus of extensive investigations to elucidate mechanisms and optimize performance. Three-dimensional (3D) simulations are often conducted with the finite element method (FEM) using the Pennes' bioheat equation. In the current study, the Pennes' equation was modified to include a thermal damage-dependent perfusion profile to improve model predictions with respect to known physiological responses to tissue heating. A normal distribution of MNPs in a model liver tumor was combined with empirical nanoparticle heating data to calculate tumor temperature distributions and resulting survival fraction of cancer cells. In addition, calculated spatiotemporal temperature changes were compared among magnetic field amplitude modulations of a base 150-kHz sinusoidal waveform, specifically, no modulation, sinusoidal, rectangular, and triangular modulation. Complex relationships were observed between nanoparticle heating and cancer tissue damage when amplitude modulation and damage-related perfusion profiles were varied. These results are tantalizing and motivate further exploration of amplitude modulation as a means to enhance efficiency of and overcome technical challenges associated with magnetic nanoparticle hyperthermia (MNH).

引用

页码：491 / 504

页数：14

共 46 条

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