Phenolic Compounds as Potent Free Radical Scavenging and Enzyme Inhibitory Components From the Leaves of Guiera senegalensis

被引：4

作者：

Dirar, Amina Ibrahim ^{[1
,2
]}

Adhikari-Devkota, Anjana ^{[1
]}

Hassan, Md. Mahadi ^{[1
]}

Wada, Mikiyo ^{[1
]}

Watanabe, Takashi ^{[1
]}

Devkota, Hari Prasad ^{[1
,3
]}

机构：

[1] Kumamoto Univ, Grad Sch Pharmaceut Sci, Kumamoto, Japan

[2] Natl Ctr Res, Med Aromat Plants & Tradit Med Res Inst, Khartoum, Sudan

[3] Kumamoto Univ, Program Leading Grad Sch, Hlth Life Sci Interdisciplinary & Glocal Oriented, Kumamoto, Japan

来源：

NATURAL PRODUCT COMMUNICATIONS | 2019年 / 14卷 / 06期

关键词：

Guiera senegalensis; Sudan; free radical scavenging; alpha-glucosidase; pancreatic lipase; ACID; EXTRACTS; SOLVENTS; GALLATE;

D O I：

10.1177/1934578X19857364

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Guiera senegalensis J.F. Gmel. (Combretaceae) is commonly used as a traditional medicine in Africa. In our previous study, the hydro-alcoholic extracts of the leaves of G. senegalensis showed potent free radical scavenging and enzyme inhibitory activities. Detailed chemical analysis of the 70% ethanol extract afforded 8 phenolic compounds including myricetin (1), myricitrin (2), quercetin (3), (-)-gallocatechin (4), 1,3,4,5-tetra-O-galloylquinic acid (5), gallic acid (6), methyl gallate (7), and ethyl gallate (8). Structures of these compounds were elucidated on the basis of NMR spectroscopic data. Among these compounds, 1,3,4,5-tetra-O-galloylquinic acid (5) (IC50= 7.21 +/- 0.21 mu M), quercetin (3) (IC50 = 7.71 +/- 0.17 mu M), and myricitrin (2) (0.25 +/- 0.03 mu M) showed the most potent free radical scavenging, alpha-glucosidase inhibitory and pancreatic lipase inhibitory activities, respectively.

引用

页数：4

共 15 条

[1] In vitro and in vivo trypanocidal effect of lipophilic extracts of medicinal plants from Mali and Burkina Faso [J].

Aderbauer, Birgit ;

Clausen, Peter-Henning ;

Kershaw, Olivia ;

Melzig, Matthias F. .

JOURNAL OF ETHNOPHARMACOLOGY, 2008, 119 (02) :225-231

[2] Chemical constituents from the flowers of Satsuma mandarin and their free radical scavenging and α-glucosidase inhibitory activities [J].

Adhikari-Devkota, Anjana ;

Elbashir, Sara Mustafa Idris ;

Watanabe, Takashi ;

Devkota, Hari Prasad .

NATURAL PRODUCT RESEARCH, 2019, 33 (11) :1670-1673

[3] Ethnoveterinary medical practice for ruminants in the subhumid zone of northern Nigeria [J].

Alawa, JP ;

Jokthan, GE ;

Akut, K .

PREVENTIVE VETERINARY MEDICINE, 2002, 54 (01) :79-90

[4] 1,3-Di-O-galloylquinic acid from Guiera senegalensis [J].

Bouchet, N ;

Levesque, J ;

Blond, A ;

Bodo, B ;

Pousset, JL .

PHYTOCHEMISTRY, 1996, 42 (01) :189-190

[5]

Davis AL, 1996, MAGN RESON CHEM, V34, P887, DOI 10.1002/(SICI)1097-458X(199611)34:11<887::AID-OMR995>3.0.CO

[6]

2-U

[7] Effects of extraction solvents on total phenolic and flavonoid contents and biological activities of extracts from Sudanese medicinal plants [J].

Dirar, A. I. ;

Alsaadi, D. H. M. ;

Wada, M. ;

Mohamed, M. A. ;

Watanabe, T. ;

Devkota, H. P. .

SOUTH AFRICAN JOURNAL OF BOTANY, 2019, 120 :261-267

[8]

El Ghazali GEB, 1997, MED PLANTS N KORDOFA

[9]

EL-Kamali H.H., 2009, Ethnobot Leaflets, V13, P203

[10] Isolation and characterization of gallic acid and methyl gallate from the seed coats of Givotia rottleriformis Griff. and their anti-proliferative effect on human epidermoid carcinoma A431 cells [J].

Kamatham, Samuel ;

Kumar, Naresh ;

Gudipalli, Padmaja .

TOXICOLOGY REPORTS, 2015, 2 :520-529

← 1 2 →