Mitophagy mechanisms and role in human diseases

被引：114
作者：
Redmann, Matthew [1 ,2 ]
Dodson, Matthew [1 ,2 ]
Boyer-Guittaut, Michael [4 ]
Darley-Usmar, Victor [1 ,2 ]
Zhang, Jianhua [1 ,2 ,3 ]
机构：
[1] Univ Alabama Birmingham, Ctr Free Radical Biol, Birmingham, AL 35294 USA
[2] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA
[3] Birmingham VA Med Ctr, Dept Vet Affairs, Birmingham, AL 35294 USA
[4] Univ Franche Comte, Biochim Lab, EA3922, SFR IBCT FED4234, F-25030 Besancon, France
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2014年 / 53卷
关键词：
Mitochondria; Parkinson's disease; Cancer; Mitophagy; Heart disease; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS; PINK1/PARKIN-MEDIATED MITOPHAGY; ADRENOCORTICAL TUMORS; ATTENUATES MITOPHAGY; MEDIATED MITOPHAGY; MITOFUSIN; PARKIN; AUTOPHAGY; PROTEIN;
D O I：
10.1016/j.biocel.2014.05.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mitophagy is a process of mitochondrial turnover through lysosomal mediated autophagy activities. This review will highlight recent studies that have identified mediators of mitophagy in response to starvation, loss of mitochondrial membrane potential or perturbation of mitochondrial integrity. Furthermore, we will review evidence of mitophagy dysfunction in various human diseases and discuss the potential for therapeutic interventions that target mitophagy processes. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：127 / 133
页数：7
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