Targeting astrocytes in major depression

被引：62

作者：

Peng, Liang ^{[1
]}

Verkhratsky, Alexei ^{[2
,3
,4
,5
,6
]}

Gu, Li ^{[1
]}

Li, Baoman ^{[1
]}

机构：

[1] China Med Univ, Inst Metab Dis Res & Drug Dev, Lab Metab Brain Dis, Shenyang, Peoples R China

[2] Univ Manchester, Fac Life Sci, Manchester, Lancs, England

[3] Basque Fdn Sci, Ikerbasque, Achucarro Ctr Neurosci, Bilbao 48011, Spain

[4] Univ Basque Country, UPV EHU, Dept Neurosci, Leioa, Spain

[5] CIBERNED, Leioa, Spain

[6] Univ Nizhny Novgorod, Nizhnii Novgorod 603022, Russia

来源：

EXPERT REVIEW OF NEUROTHERAPEUTICS | 2015年 / 15卷 / 11期

基金：

中国国家自然科学基金; 俄罗斯科学基金会;

关键词：

astrocytes; major depression; mechanism of drug action; neuropsychiatric diseases; serotonin-specific reuptake inhibitors; NEUROTROPHIC-FACTOR; GROWTH-FACTOR; TRICYCLIC ANTIDEPRESSANT; GLUTAMATE UPTAKE; KIR4.1; CHANNELS; RAT; FLUOXETINE; EXPRESSION; INHIBITION; RILUZOLE;

D O I：

10.1586/14737175.2015.1095094

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Astrocytes represent a highly heterogeneous population of neural cells primarily responsible for the homeostasis of the CNS. Astrocytes express multiple receptors for neurotransmitters, including the serotonin 5-HT2B receptors and interact with neurones at the synapse. Astroglia contribute to neurological diseases through homeostatic response, neuroprotection and reactivity. In major depression, astrocytes show signs of degeneration and are decreased in numbers, which may lead to a misbalance in neurotransmission and aberrant synaptic connectivity. In this review, we summarize astroglia-specific effects of major antidepressants and outline future strategies for astroglia-specific therapy in neuropsychiatric disorders.

引用

页码：1299 / 1306

页数：8

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