Synthesis of 14,20-Bis-epi-1α,25-dihydroxy 19-norvitamin D3 and analogues

被引：0

作者：

Van Gool, M ^{[1
]}

Zhao, XY ^{[1
]}

Sabbe, K ^{[1
]}

Vandewalle, M ^{[1
]}

机构：

[1] Univ Ghent, Dept Organ Chem, Synth Organ Lab, B-9000 Ghent, Belgium

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 1999卷 / 09期

关键词：

14,20-Bis-epi Inhoffen-Lythgoe diol; Hajos-Wiechert ketone; enantiomeric purity; acyclic diastereoselective; alkylation; alkylations; hydroborations; epimerisation;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

14,20-Bis-epi-1 alpha,25-dihydroxy-19-norvitamin D-3 and side chain analogues thereof have been synthesised via the 14,20-bis-epi-Inhoffen-Lythgoe diol 9. The synthesis of this precursor was performed via degradation of vitamin D-2 and by total synthesis starting from Hajos-Wiechert ketone 24.

引用

页码：2241 / 2248

页数：8

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