Results of a prospective phase II trial evaluating interim positron emission tomography-guided high dose therapy for poor prognosis diffuse large B-cell lymphoma

被引：22

作者：

Stewart, Douglas A. ^{[1
]}

Kloiber, Reinhard ^{[2
]}

Owen, Carolyn ^{[1
]}

Bahlis, Nizar J. ^{[1
]}

Duggan, Peter ^{[1
]}

Mansoor, Adnan ^{[1
]}

Bence-Bruckler, Isabelle ^{[3
]}

机构：

[1] Univ Calgary, Calgary, AB, Canada

[2] Foothills Med Ctr, Calgary, AB, Canada

[3] Univ Ottawa, Ottawa, ON, Canada

来源：

LEUKEMIA & LYMPHOMA | 2014年 / 55卷 / 09期

关键词：

Hematopoietic stem cell transplant; positron emission tomography; diffuse large B-cell lymphoma; NON-HODGKIN-LYMPHOMA; FDG-PET; INTERNATIONAL WORKSHOP; AGGRESSIVE LYMPHOMA; SALVAGE THERAPY; F-18-FDG PET; CHEMOTHERAPY; SURVIVAL; PREDICT; IMMUNOHISTOCHEMISTRY;

D O I：

10.3109/10428194.2013.862242

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with diffuse large B-cell lymphoma (DLBCL) with a poor prognosis based upon advanced stage and elevated serum lactate dehydrogenase achieve a 3-4-year progression-free survival (PFS) of only 55%. The role of interim fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) to guide use of upfront high dose chemotherapy (HDCT) and autologous stem cell transplant (ASCT) for patients with poor prognosis DLBCL is unproven. A prospective phase II clinical trial was designed to evaluate the outcomes of HDCT/ASCT for patients with poor prognosis DLBCL aged 18-65 years who had unfavorable interim restaging PET scans. Of the 70 eligible patients, 36 had unfavorable and 34 favorable interim PET responses, with 3-year PFS rates of 65.2% and 52.7%, respectively. In conclusion, favorable interim PET response as defined in this study is not associated with improved PFS rates for patients with poor prognosis DLBCL treated with RCHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone). A phase III trial evaluating this PET-guided approach is not warranted.

引用

页码：2064 / 2070

页数：7

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