Synthesis and activity of 1H-benzimidazole and 1H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii

被引：116
作者：
Kopanska, K
Najda, A
Zebrowska, J
Chomicz, L
Piekarczyk, J
Myjak, P
Bretner, M
机构：
[1] Polish Acad Sci, Inst Biochem & Biophys, PL-02106 Warsaw, Poland
[2] Med Univ Warsaw, Dept Med Biol, PL-02018 Warsaw, Poland
[3] Med Univ Warsaw, Dept Maxillofacial Surg 2, PL-02005 Warsaw, Poland
[4] Med Univ Gdansk, Dept Trop Parasitol, PL-081516 Gdynia, Poland
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2004年 / 12卷 / 10期
关键词：
analogues of 1H-benzimidazole; analogues of 1H-benzotriazole; Acanthamoeba castellanii; antiprotozoal activity;
D O I：
10.1016/j.bmc.2004.03.022
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chloro-, bromo- and methyl- analogues of 1H-benzimidazole and 1H-benzotriazole and their N-alkyl derivatives have been synthesized and tested in vitro against the protozoa Acanthamoeba castellanii. The results indicate that 5,6-dimethyl-1H-benzotriazole (11) and 5,6-dibromo-1H-benzotriazole (14) have higher efficacy than the antiprotozoal agent chlorohexidine. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：2617 / 2624
页数：8
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