Bacterial co-infection and early mortality among pulmonary tuberculosis patients in Manila, The Philippines

被引:20
作者
Shimazaki, T. [1 ]
Taniguchi, T. [1 ]
Saludar, N. R. D. [2 ]
Gustilo, L. M. [2 ]
Kato, T. [3 ]
Furumoto, A. [1 ]
Kato, K. [4 ,5 ]
Saito, N. [1 ]
Go, W. S. [2 ]
Tria, E. S. [2 ]
Salva, E. P. [2 ]
Dimaano, E. M. [2 ]
Parry, C. [5 ]
Ariyoshi, K. [1 ]
Villarama, J. B. [2 ]
Suzuki, M. [1 ]
机构
[1] Nagasaki Univ, Inst Trop Med, Dept Clin Med, 1-12-4 Sakamoto, Nagasaki 8528523, Japan
[2] San Lazaro Hosp, Manila, Philippines
[3] Japan AntiTB Assoc, Dept Mycobacterium Reference & Res, Res Inst TB, Bacteriol Div, Tokyo, Japan
[4] Nagasaki Univ, Inst Trop Med, Dept Parasitol, Nagasaki, Japan
[5] Nagasaki Univ, Sch Trop Med & Global Hlth, Nagasaki, Japan
关键词
Mycobacterium tuberculosis; bacterial pneumonia; early tuberculosis death; MYCOBACTERIUM-TUBERCULOSIS; RISK-FACTORS; DIAGNOSIS; DEATH; INFECTION; COUNTRIES; ADULTS;
D O I
10.5588/ijtld.17.0389
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
OBJECTIVE : To investigate the prevalence of bacterial co-infection and its effect on early mortality among hospitalised human immunodeficiency virus (HIV) negative pulmonary tuberculosis (PTB) patients in Manila, the Philippines. DESIGN: A prospective observational study was conducted at a national infectious disease hospital. HIV-negative PTB patients age >= 713 years hospitalised from November to December 2011 and from December 2012 to May 2013 were enrolled. Sputum samples were tested for Mycobacterium tuberculosis and six respiratory bacterial pathogens using polymerase chain reaction (PCR). RESULTS : Of 466 patients, 228 (48.9%) were TB-PCR-positive. Overall, bacterial pathogens in purulent sputum were detected in 135 (29.0%) patients: Haemophilus influenzae was the most common bacterium (21.2%), followed by Streptococcus pneumoniae (7.9%). The prevalence of bacterial co-infection did not differ between TB-PCR-positive and -negative patients. A total of 92 (19.7%) patients died within 2 weeks. Bacterial co-infection was significantly associated with an increased risk of 2-week mortality among TB-PCR-positive patients (adjusted risk ratio [aRR] 1.67, 95% CI 1.03-2.72). This association was also observed but did not reach statistical significance among TB-PCR-negative patients (aRR1.7, 95% CI 0.95-3.02). CONCLUS ION: Bacterial co-infection is common and contributes to an increased risk of early mortality among HIV-negative PTB patients.
引用
收藏
页码:65 / +
页数:10
相关论文
共 28 条
  • [1] Alvarez GG, 2004, INT J TUBERC LUNG D, V8, P1472
  • [2] The usefulness of changing focus during examination using Gram staining as initial diagnostic clue for infective tuberculosis
    Atsukawa, Yoshiko
    Kawakami, Sayoko
    Asahara, Miwa
    Ishigaki, Shinobu
    Tanaka, Takashi
    Ono, Yasuo
    Nishiya, Hajime
    Fujisaki, Ryuichi
    Koga, Ichiro
    Ota, Yasuo
    Miyazawa, Yukihisa
    [J]. JOURNAL OF INFECTION AND CHEMOTHERAPY, 2011, 17 (04) : 571 - 574
  • [3] Comparison of an internally controlled, large-volume LightCycler assay for detection of Mycobacterium tuberculosis in clinical samples with the COBAS AMPLICOR assay
    Burggraf, S
    Reischl, U
    Malik, N
    Bollwein, M
    Naumann, L
    Olgemöller, B
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (04) : 1564 - 1569
  • [4] TUBERCULOSIS - CAUSE OF DEATH IN ANTIBIOTIC ERA
    DAVIS, CE
    CARPENTER, JL
    MCALLISTER, CK
    MATTHEWS, J
    BUSH, BA
    OGNIBENE, AJ
    [J]. CHEST, 1985, 88 (05) : 726 - 729
  • [5] Erhabor G E, 2006, Indian J Chest Dis Allied Sci, V48, P253
  • [6] Concomitant Pulmonary Tuberculosis in Hospitalized Healthcare-Associated Pneumonia in a Tuberculosis Endemic Area: A Multi-center Retrospective Study
    Feng, Jia-Yih
    Fang, Wen-Feng
    Wu, Chieh-Liang
    Yu, Chong-Jen
    Lin, Meng-Chih
    Ku, Shih-Chi
    Chen, Yu-Chun
    Chen, Chang-Wen
    Tu, Chih-Yen
    Su, Wei-Juin
    Yang, Kuang-Yao
    [J]. PLOS ONE, 2012, 7 (05):
  • [7] Lower airway colonization and inflammatory response in COPD: a focus on Haemophilus influenzae
    Finney, Lydia J.
    Ritchie, Andrew
    Pollard, Elizabeth
    Johnston, Sebastian L.
    Mallia, Patrick
    [J]. INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2014, 9 : 1119 - 1132
  • [8] Gangcuangco Louie Mar A, 2013, Southeast Asian J Trop Med Public Health, V44, P810
  • [9] GECKLER RW, 1977, J CLIN MICROBIOL, V6, P396
  • [10] Diagnosis of smear-negative pulmonary tuberculosis in people with HIV infection or AIDS in resource-constrained settings: informing urgent policy changes
    Getahun, Haileyesus
    Harrington, Mark
    O'Brien, Rick
    Nunn, Paul
    [J]. LANCET, 2007, 369 (9578) : 2042 - 2049