Microporous biocomposite scaffolds with tunable degradation and interconnected microarchitecture-A synergistic integration of bioactive chain silicate glass-ceramic and poly(ε-caprolactone)

被引：20

作者：

Kumawat, Vijay Shankar ^{[1
]}

Ghosh, Subrata Bandhu ^{[1
]}

Bandyopadhyay-Ghosh, Sanchita ^{[1
]}

机构：

[1] Manipal Univ Jaipur, Dept Mech Engn, Jaipur 303007, Rajasthan, India

来源：

POLYMER DEGRADATION AND STABILITY | 2019年 / 165卷

关键词：

Biopolymer; Poly(epsilon-caprolactone); Chain-silicate glass-ceramic; Micro-fluorcanasite; Biocomposite; Bone scaffold; Biodegradation; Microporous; COMPOSITE SCAFFOLDS; BONE; FABRICATION; HYDROXYAPATITE; BIOMATERIALS;

D O I：

10.1016/j.polymdegradstab.2019.04.017

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This study reports, for the first time, incorporation of micro-fluorcanasite (AFC) chain silicate glass ceramic particulates as a potential bioactive reinforcement for development of biocomposite bone scaffolds. Micro-fluorcanasite glass-ceramic particulates were dispersed in a systematic manner within poly(e-caprolactone) (PCL) biopolymer at different loading levels. Biocomposite scaffolds were then fabricated through thermally induced phase separation (TIPS) technique. X-ray diffraction studies of AFC revealed generation of targeted fluorcanasite and frankamenite phases, while reinforced biocomposite scaffolds indicated presence of PCL and additional crystalline phases. Scanning electron microscopy and Fourier transform infrared spectroscopy studies revealed interconnected porosity, micro-architectural details and successful incorporation of AFC within PCL matrix, indicating supportive physiological environment for bone tissue growth. The biocomposite scaffolds upon immersion in Hank's solution for different intervals, further established tunable biodegradability of the scaffolds. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：20 / 26

页数：7

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