Micafungin at Physiological Serum Concentrations Shows Antifungal Activity against Candida albicans and Candida parapsilosis Biofilms

被引：15

作者：

Guembe, M. ^{[1
,2
]}

Guinea, J. ^{[1
,2
,3
,4
]}

Marcos-Zambrano, L. J. ^{[1
,2
]}

Fernandez-Cruz, A. ^{[1
,2
]}

Pelaez, T. ^{[1
,2
,3
,4
]}

Munoz, P. ^{[1
,2
,3
,4
]}

Bouza, E. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Gregorio Maranon, Gen Hosp, Dept Clin Microbiol & Infect Dis, Madrid, Spain

[2] Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain

[3] CIBER Enfermedades Resp CIBERES, Madrid, Spain

[4] Univ Complutense Madrid, Sch Med, Dept Med, Madrid, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 09期

关键词：

CENTRAL VENOUS CATHETER; BLOOD-STREAM INFECTION; IN-VITRO ACTIVITY; NATIONAL SURVEILLANCE; AMPHOTERICIN-B; SECULAR TRENDS; SUSCEPTIBILITY; ANIDULAFUNGIN; CASPOFUNGIN; MODEL;

D O I：

10.1128/AAC.02738-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We assessed the in vitro activity of micafungin against preformed Candida biofilms by measuring the concentration of drug causing the most fungal damage and inhibition of regrowth. We studied 37 biofilm-producing Candida spp. strains from blood cultures. We showed that micafungin was active against planktonic and sessile forms of Candida albicans strains and moderately active against Candida parapsilosis sessile cells. Concentrations of micafungin above 2 mu g/ml were sufficiently high to inactivate regrowth of Candida sessile cells.

引用

页码：5581 / 5584

页数：4

共 43 条

[1] Penetration of Candida biofilms by antifungal agents [J].

Al-Fattani, MA ;

Douglas, LJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (09) :3291-3297

[2] EUCAST technical note on the EUCAST definitive document EDef 7.2: method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for yeasts EDef 7.2 (EUCAST-AFST) [J].

Arendrup, Maiken C. ;

Cuenca-Estrella, Manuel ;

Lass-Floerl, Cornelia ;

Hope, William .

CLINICAL MICROBIOLOGY AND INFECTION, 2012, 18 (07) :E246-E247

[3] SECULAR TRENDS IN NOSOCOMIAL PRIMARY BLOOD-STREAM INFECTIONS IN THE UNITED-STATES, 1980-1989 [J].

BANERJEE, SN ;

EMORI, TG ;

CULVER, DH ;

GAYNES, RP ;

JARVIS, WR ;

HORAN, T ;

EDWARDS, JR ;

TOLSON, J ;

HENDERSON, T ;

MARTONE, WJ .

AMERICAN JOURNAL OF MEDICINE, 1991, 91 :S86-S89

[4] Efficacy of anidulafungin against biofilms of different Candida species in long-term trials of continuous flow cultivation [J].

Bernhardt, Hannelore ;

Knoke, Manfred ;

Bernhardt, Joern .

MYCOSES, 2011, 54 (06) :E821-E827

[5] Pharmacodynamics and pharmacokinetics of micafungin in adults, children and neonate [J].

Catalan-Gonzalez, Mercedes ;

Carlos Montejo-Gonzalez, Juan .

REVISTA IBEROAMERICANA DE MICOLOGIA, 2009, 26 (01) :23-34

[6] In vitro efficacies of caspofungin or micafungin catheter lock solutions on Candida albicans biofilm growth [J].

Cateau, Estelle ;

Rodier, Marie-Helene ;

Imbert, Christine .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 62 (01) :153-155

[7] Possible role of azole and echinocandin lock solutions in the control of Candida biofilms associated with silicone [J].

Cateau, Estelle ;

Berjeaud, Jean-Marc ;

Imbert, Christine .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2011, 37 (04) :380-384

[8] Biofilm formation by five species of Candida on three clinical materials [J].

Estivill, D. ;

Arias, A. ;

Torres-Lana, A. ;

Carrillo-Munoz, A. J. ;

Arevalo, M. P. .

JOURNAL OF MICROBIOLOGICAL METHODS, 2011, 86 (02) :238-242

[9] Biofilm Formation and Effect of Caspofungin on Biofilm Structure of Candida Species Bloodstream Isolates [J].

Ferreira, J. A. G. ;

Carr, J. H. ;

Starling, C. E. F. ;

de Resende, M. A. ;

Donlan, R. M. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (10) :4377-4384

[10] Secular trends of candidemia over 12 years in adult patients at a tertiary care hospital [J].

Garbino, J ;

Kolarova, L ;

Rohner, P ;

Lew, D ;

Pichna, P ;

Pittet, D .

MEDICINE, 2002, 81 (06) :425-433

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