Tumor microenvironment: regulatory cells and immunosuppressive cytokines

被引：11
作者：
Bruchard, Melanie [1 ]
Ghiringhelli, Francois [1 ,2 ]
机构：
[1] Fac Med & Pharm Dijon, INSERM, Dijon, France
[2] Ctr Georges Francois Leclerc, Dijon, France
来源：
M S-MEDECINE SCIENCES | 2014年 / 30卷 / 04期
关键词：
T-CELLS; SUPPRESSOR-CELLS; DENDRITIC CELLS; GROWTH-FACTOR; CANCER; INTERLEUKIN-6; INFLAMMATION; TH17; SUBPOPULATIONS; MECHANISMS;
D O I：
10.1051/medsci/20143004018
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Immunosuppression is a mechanism developed by cancer cells to help them escape the immune system. Immunosuppression involves expansion of various cell types and production of a variety of cytokines. In this review, we explore the duality of three cancer induced cell populations, regulatory T lymphocytes, Th17 lymphocytes and MDSC, and also the pleiotropic effects of several cytokines induced during cancer development.
引用
收藏
页码：429 / 435
页数：7
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