Tumor microenvironment: regulatory cells and immunosuppressive cytokines

被引：11
|
作者：
Bruchard, Melanie [1 ]
Ghiringhelli, Francois [1 ,2 ]
机构：
[1] Fac Med & Pharm Dijon, INSERM, Dijon, France
[2] Ctr Georges Francois Leclerc, Dijon, France
来源：
M S-MEDECINE SCIENCES | 2014年 / 30卷 / 04期
关键词：
T-CELLS; SUPPRESSOR-CELLS; DENDRITIC CELLS; GROWTH-FACTOR; CANCER; INTERLEUKIN-6; INFLAMMATION; TH17; SUBPOPULATIONS; MECHANISMS;
D O I：
10.1051/medsci/20143004018
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Immunosuppression is a mechanism developed by cancer cells to help them escape the immune system. Immunosuppression involves expansion of various cell types and production of a variety of cytokines. In this review, we explore the duality of three cancer induced cell populations, regulatory T lymphocytes, Th17 lymphocytes and MDSC, and also the pleiotropic effects of several cytokines induced during cancer development.
引用
收藏
页码：429 / 435
页数：7
相关论文
共 50 条
  • [1] Immunosuppressive mechanisms of the tumor microenvironment by regulatory T cells
    Koyama, Shohei
    Nishikawa, Hiroyoshi
    CANCER SCIENCE, 2023, 114 : 88 - 88
  • [2] Preferential accumulation of regulatory T cells with highly immunosuppressive characteristics in breast tumor microenvironment
    Khaja, Azharuddin Sajid Syed
    Toor, Salman M.
    El Salhat, Haytham
    Faour, Issam
    Haq, Navid Ul
    Ali, Bassam R.
    Elkord, Eyad
    ONCOTARGET, 2017, 8 (20) : 33159 - 33171
  • [3] Regulatory T Cells in the Tumor Microenvironment
    Dadey, Rebekah E.
    Workman, Creg J.
    Vignali, Dario A. A.
    TUMOR MICROENVIRONMENT: HEMATOPOIETIC CELLS, PT B, 2020, 1273 : 105 - 134
  • [4] The microenvironment in primary cutaneous melanoma with associated spontaneous tumor regression: evaluation for T-regulatory cells and the presence of an immunosuppressive microenvironment
    Gray, Arielle
    Grushchak, Solomiya
    Mudaliar, Kumaran
    Kliethermes, Stephanie
    Carey, Kyle
    Hutchens, Kelli A.
    MELANOMA RESEARCH, 2017, 27 (02) : 104 - 109
  • [5] Tumor-Associated Macrophages as Major Immunosuppressive Cells in the Tumor Microenvironment
    Ghebremedhin, Anghesom
    Athavale, Dipti
    Zhang, Yanting
    Yao, Xiaodan
    Balch, Curt
    Song, Shumei
    CANCERS, 2024, 16 (19)
  • [6] The Functional Crosstalk between Myeloid-Derived Suppressor Cells and Regulatory T Cells within the Immunosuppressive Tumor Microenvironment
    Haist, Maximilian
    Stege, Henner
    Grabbe, Stephan
    Bros, Matthias
    CANCERS, 2021, 13 (02) : 1 - 34
  • [7] Role of regulatory T cells in the tumor microenvironment
    Koyama, Shohei
    CANCER SCIENCE, 2024, 115 : 1501 - 1501
  • [8] Immunosuppressive enzymes in the tumor microenvironment
    Molinier-Frenkel, Valerie
    Castellano, Flavia
    FEBS LETTERS, 2017, 591 (19) : 3135 - 3157
  • [9] The immunosuppressive landscape in tumor microenvironment
    Liu, Wuyi
    Zhou, Huyue
    Lai, Wenjing
    Hu, Changpeng
    Xu, Rufu
    Gu, Peng
    Luo, Menglin
    Zhang, Rong
    Li, Guobing
    IMMUNOLOGIC RESEARCH, 2024, 72 (04) : 566 - 582
  • [10] Functional Regulation of Ginsenosides on Myeloid Immunosuppressive Cells in the Tumor Microenvironment
    Zhang, Yanfei
    Qiu, Zhidong
    Qiu, Ye
    Su, Ting
    Qu, Peng
    Jia, Ailing
    INTEGRATIVE CANCER THERAPIES, 2019, 18
12345