Analysis of cell-mediated immune responses in support of dengue vaccine development efforts

被引：10

作者：

Rothman, Alan L. ^{[1
,2
]}

Currier, Jeffrey R. ^{[3
]}

Friberg, Heather L. ^{[3
]}

Mathew, Anuja ^{[1
,2
]}

机构：

[1] Univ Rhode Isl, Inst Immunol & Informat, Providence, RI 02903 USA

[2] Univ Rhode Isl, Dept Cell & Mol Biol, Providence, RI 02903 USA

[3] Walter Reed Army Inst Res, Virus Dis Branch, Silver Spring, MD USA

来源：

VACCINE | 2015年 / 33卷 / 50期

关键词：

Dengue; Cell-mediated immunity; Vaccine; CD8(+) T-CELL; QUALITY-ASSURANCE PROGRAM; VIRUS-INFECTION; HEMORRHAGIC-FEVER; SECONDARY INFECTION; ANTIBODY-RESPONSE; CROSS-REACTIVITY; PROTECTIVE ROLE; FLOW-CYTOMETRY; CLINICAL-TRIAL;

D O I：

10.1016/j.vaccine.2015.09.104

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dengue vaccine development has made significant strides, but a better understanding of how vaccine-induced immune responses correlate with vaccine efficacy can greatly accelerate development, testing, and deployment as well as ameliorate potential risks and safety concerns. Advances in basic immunology knowledge and techniques have already improved our understanding of cell-mediated immunity of natural dengue virus infection and vaccination. We conclude that the evidence base is adequate to argue for inclusion of assessments of cell-mediated immunity as part of clinical trials of dengue vaccines, although further research to identify useful correlates of protective immunity is needed. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：7083 / 7090

页数：8

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