Ligand-Controlled Asymmetric Arylation of Aliphatic α-Amino Anion Equivalents

被引：110

作者：

Zhu, Ye ^{[1
]}

Buchwald, Stephen L. ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 12期

基金：

美国国家卫生研究院;

关键词：

BOND-FORMING REACTIONS; N-BOC-PYRROLIDINE; ENANTIOSELECTIVE SYNTHESIS; TERT-BUTANESULFINAMIDE; HOMOALLYLIC AMINES; CROSS-COUPLINGS; IMINES; ALDEHYDES; CARBON; ALLYLATION;

D O I：

10.1021/ja501560x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium-catalyzed asymmetric arylation of 9-aminofluorene-derived imines using a chiral dialkyl-biaryl phosphine as the supporting ligand has been developed. This transformation allows for enantioselective access to a diverse range of alpha-branched benzylamines.

引用

收藏

页码：4500 / 4503

页数：4

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