Application of the EMIT 2000 Tacrolimus assay on the Abbott Architect c8000 high volume clinical chemistry analyzer

被引：16

作者：

Boer, Klas ^{[1
]}

Deufel, Thomas ^{[1
]}

Schmidt, Dirk ^{[1
]}

Streck, Sibylle ^{[1
]}

Kiehntopf, Michael ^{[1
]}

机构：

[1] Inst Klin Chem & Labordiagnost FSU, Jena, Germany

来源：

CLINICAL BIOCHEMISTRY | 2006年 / 39卷 / 10期

关键词：

EMIT; tacrolimus; architect; TDM; c8000;

D O I：

10.1016/j.clinbiochem.2006.06.011

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objectives: Evaluation of the performance of the EMIT 2000 Tacrolimus assay on the Abbott Architect c8000 analyzer. Design and Methods: Imprecision studies were performed and patient samples were assayed by EMIT assay and by LC-MS/MS. Results: Limit of quantification was established at 2.8 mu g/L. A positive bias of 17.5% between results measured on EMIT and on LC-MS/MS was detected. Conclusions: EMIT 2000 Tacrolimus assay is suitable for automated analyses of Tacrolimus on the Architect c8000. (c) 2006 The Canadian Society of Clinical Chemists. All rights reserved.

引用

页码：1041 / 1043

页数：3

共 9 条

[1]

BEHRING D, 2004, EMIT 2000 TACROLIMUS

[2] Low hematocrit and serum albumin concentrations underlie the overestimation of tacrolimus concentrations by microparticle enzyme immunoassay versus liquid chromatography-tandem mass spectrometry [J].