Synthesis of enantiopure antiobesity drug lorcaserin

被引：11

作者：

Smilovic, Ivana Gazic ^{[1
]}

Cluzeau, Jerome ^{[1
]}

Richter, Frank ^{[2
]}

Nerdinger, Sven ^{[2
]}

Schreiner, Erwin ^{[2
]}

Laus, Gerhard ^{[3
]}

Schottenberger, Herwig ^{[3
]}

机构：

[1] Lek Pharmaceut DD, Kolodvorska 27, Menges 1234, Slovenia

[2] Sandoz GmbH, Biochemiestr 10, A-6250 Kundl, Austria

[3] Leopold Franzens Univ, Innrain 80-82, A-6020 Innsbruck, Austria

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2018年 / 26卷 / 09期

关键词：

Enantiopure; Lorcaserin; Obesity; 5-HT agonist; OBESITY;

D O I：

10.1016/j.bmc.2018.02.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acylation of enantiomerically pure (R)-2-(3-chlorophenyl)propan-1-amine using chloroacetyl chloride, followed by borane reduction and aluminum chloride catalyzed cyclization yielded enantiopure lorcaserin. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：2686 / 2690

页数：5

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