A highly selective fluorescent probe for Fe3+ in living cells: a stress induced cell based model study

被引：33

作者：

Sharma, Neetu ^{[1
]}

Reja, Shahi Imam ^{[1
]}

Gupta, Neha ^{[1
]}

Bhalla, Vandana ^{[1
]}

Kaur, Davinder ^{[2
]}

Arora, Saroj ^{[2
]}

Kumar, Manoj ^{[1
]}

机构：

[1] Guru Nanak Dev Univ, Dept Chem, UGC Sponsored Ctr Adv Studies 2, Amritsar, Punjab, India

[2] Guru Nanak Dev Univ, Dept Bot & Environm Sci, Amritsar, Punjab, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 04期

关键词：

IRON; IONS; SYSTEMS; POOLS; TRANSLOCATION; MITOCHONDRIA; CHEMOSENSOR; REDUCTION; LYSOSOMES; SENSORS;

D O I：

10.1039/c6ob02209j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A rhodamine-phenanthroline dyad based fluorescent probe 4 has been designed and synthesized which selectively monitors Fe3+ ions among the various metal ions tested. Furthermore, probe 4 has been explored for monitoring of dynamic changes in the Fe3+ ion level under aggressive Fenton reaction conditions using a cell based model study. More significantly, probe 4 has also been utilized for real time imaging of endogenous Fe3+ ions in living C6 cell lines, the results of which demonstrated that probe 4 acts as an efficient fluorescent tool for Fe3+ ion detection in biological systems.

引用

页码：1006 / 1012

页数：7

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