Schisanwilsonenes A-C, Anti-HBV Carotane Sesquiterpenoids from the Fruits of Schisandra wilsoniana

被引：46

作者：

Ma, Wen-Hui ^{[1
]}

Huang, Hai ^{[2
]}

Zhou, Pei ^{[2
]}

Chen, Dao-Feng ^{[1
]}

机构：

[1] Fudan Univ, Sch Pharm, Dept Pharmacognosy, Shanghai 200032, Peoples R China

[2] Fudan Univ, Sch Pharm, Dept Biosynthet Med Chem, Shanghai 200032, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 04期

基金：

中国国家自然科学基金;

关键词：

SCHIZANDRA-ARISANENSIS; HEPATITIS; LIGNANS; STEMS;

D O I：

10.1021/np8007864

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three carotane-type sesquiterpenoids, schisanwilsonenes A (1), B (2), and C (3), were isolated from the fruits of Schisandra wilsoniana. Their structures and relative configurations were elucidated on the basis of spectroscopic methods including 2D-NMR techniques, and the structure of 1 was confirmed by a single-crystal X-ray diffraction experiment. Schisanwilsonene A, at 50 mu g/mL, exhibited antiviral activity, inhibiting HBsAg and HBeAg secretion by 76.5% and 28.9%.

引用

页码：676 / 678

页数：3

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