Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation

被引：56

作者：

Chen, Yu ^{[1
,2
,3
]}

Aguirre, Aaron D. ^{[1
,2
,4
]}

Ruvinskaya, Lana ^{[5
]}

Devor, Anna ^{[5
,6
,7
]}

Boas, David A. ^{[4
,5
]}

Fujimoto, James G. ^{[1
,2
]}

机构：

[1] MIT, Elect Res Lab, Cambridge, MA 02139 USA

[2] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA

[3] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA

[4] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[5] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Martinos Ctr Biomed Imaging,Dept Radiol, Charlestown, MA 02129 USA

[6] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92093 USA

[7] Univ Calif San Diego, Dept Radiol, San Diego, CA 92093 USA

来源：

JOURNAL OF NEUROSCIENCE METHODS | 2009年 / 178卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Optical coherence tomography (OCT); Functional optical coherence tomography; Optical intrinsic signal imaging (OISI); Depth-resolved functional dynamics; Somatosensory cortex; Scattering change; Retrograde vessel dilation; RAT SOMATOSENSORY CORTEX; NEURONAL-ACTIVITY; IN-VIVO; VISUAL-CORTEX; BLOOD-FLOW; NEURAL ACTIVITY; HEMODYNAMIC-CHANGES; RETINAL PHYSIOLOGY; SCATTERING CHANGES; OXYGEN-METABOLISM;

D O I：

10.1016/j.jneumeth.2008.11.026

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Optical intrinsic signal imaging (OISI) provides two-dimensional, depth-integrated activation maps of brain activity. Optical coherence tomography (OCT) provides depth-resolved, cross-sectional images of functional brain activation. Co-registered OCT and OISI imaging was performed simultaneously on the rat somatosensory cortex through a thinned skull during forepaw electrical stimulation. Fractional signal change measurements made by OCT revealed a functional signal that correlates well with that of the intrinsic hemodynamic signals and provides depth-resolved, layer-specific dynamics in the functional activation patterns indicating retrograde vessel dilation. OCT is a promising a new technology which provides complementary information to OISI for functional neuroimaging. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：162 / 173

页数：12

共 46 条

[1] Depth-resolved imaging of functional activation in the rat cerebral cortex using optical coherence tomography [J].

Aguirre, A. D. ;

Chen, Y. ;

Fujimoto, J. G. ;

Ruvinskaya, L. ;

Devor, A. ;

Boas, D. A. .

OPTICS LETTERS, 2006, 31 (23) :3459-3461

[2] Detection of neural activity using phase-sensitive optical low-coherence reflectometry [J].

Akkin, T ;

Davé, DP ;

Milner, TE ;

Rylander, HG .

OPTICS EXPRESS, 2004, 12 (11) :2377-2386

[3] High-resolution optical coherence tomography imaging of the living kidney [J].

Andrews, Peter M. ;

Chen, Yu ;

Onozato, Maristela L. ;

Huang, Shu-Wei ;

Adler, Desmond C. ;

Huber, Robert A. ;

Jiang, James ;

Barry, Scott E. ;

Cable, Alex E. ;

Fujimoto, James G. .

LABORATORY INVESTIGATION, 2008, 88 (04) :441-449

[4] Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-β ligand in transgenic mice [J].

Bacskai, BJ ;

Hickey, GA ;

Skoch, J ;

Kajdasz, ST ;

Wang, YM ;

Huang, GF ;

Mathis, CA ;

Klunk, WE ;

Hyman, BT .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (21) :12462-12467

[5] Optophysiology: Depth-resolved probing of retinal physiology with functional ultrahigh-resolution optical coherence tomography [J].

Bizheva, K ;

Pflug, R ;

Hermann, B ;

Povazay, B ;

Sattmann, H ;

Qiu, P ;

Anger, E ;

Reitsamer, H ;

Popov, S ;

Taylor, JR ;

Unterhuber, A ;

Ahnelt, P ;

Drexler, W .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (13) :5066-5071

[6] Ultrahigh resolution real time OCT imaging using a compact femtosecond Nd:Glass laser and nonlinear fiber [J].

Bourquin, S ;

Aguirre, AD ;

Hartl, I ;

Hsiung, P ;

Ko, TH ;

Fujimoto, JG ;

Birks, TA ;

Wadsworth, WJ ;

Bünting, U ;

Kopf, D .

OPTICS EXPRESS, 2003, 11 (24) :3290-3297

[7] Two-photon imaging of capillary blood flow in olfactory bulb glomeruli [J].

Chaigneau, E ;

Oheim, M ;

Audinat, E ;

Charpak, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (22) :13081-13086

[8] Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography [J].

Chen, ZP ;

Milner, TE ;

Srinivas, S ;

Wang, XJ ;

Malekafzali, A ;

vanGemert, MJC ;

Nelson, JS .

OPTICS LETTERS, 1997, 22 (14) :1119-1121

[9] Sensitivity advantage of swept source and Fourier domain optical coherence tomography [J].

Choma, MA ;

Sarunic, MV ;

Yang, CH ;

Izatt, JA .

OPTICS EXPRESS, 2003, 11 (18) :2183-2189

[10] Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography [J].

de Boer, JF ;

Cense, B ;

Park, BH ;

Pierce, MC ;

Tearney, GJ ;

Bouma, BE .

OPTICS LETTERS, 2003, 28 (21) :2067-2069

← 1 2 3 4 5 →