The level of IL-6 was associated with sleep disturbances in patients with major depressive disorder

Purpose: Major depression disorder (MDD) was associated with inflammatory processes, but association results of inflammatory syndrome and MDD were inconsistent. To provide more evidence, we measured the plasma levels of IL-1 beta, IL-6, interferon (INT)-alpha 2, INT-gamma, and tumor necrosis factor (TNF)-alpha in patients having MDD and explored correlations between the five proinflammatory cytokines and specific depressive symptoms. Patients and methods: Plasma concentrations of IL-1 beta, IL-6, INT-alpha 2, INT-gamma, and TNF-alpha were measured using ELISA for 44 MDD patients and 54 healthy controls. Patients with MDD were assessed on the 17-item Hamilton Depression Rating Scale (HAMD-17), and a total score and five syndrome scores were acquired. Results: IL-6 levels in depressed patients were significantly elevated than in healthy controls, but no significant differences were observed in the levels of INF-alpha 2, INF-gamma, IL-1 beta, or TNF-alpha. In addition, con elation analysis revealed that sleep disturbances positively correlated with IL-6. Although there was no significant difference between the two groups in the levels of INF-alpha 2, a significant positive correlation between IFN-alpha 2 and retardation was observed. Conclusion: Elevated IL-6 levels were observed in MDD patients and IL-6 may correlate with sleep disturbances.