Sodium Channel Blockers for the Treatment of Neuropathic Pain

被引：55

作者：

Bhattacharya, Anindya ^{[1
]}

Wickenden, Alan D. ^{[1
]}

Chaplan, Sandra R. ^{[1
]}

机构：

[1] Johnson & Johnson Pharmaceut Res & Dev LLC, Pain & Related Disorders Team, San Diego, CA 92121 USA

来源：

NEUROTHERAPEUTICS | 2009年 / 6卷 / 04期

关键词：

Sodium channel; subtype; selectivity; neuropathic pain; drug discovery; RANDOMIZED CONTROLLED-TRIAL; PLACEBO-CONTROLLED TRIAL; PERIPHERAL-NERVE INJURY; DORSAL-ROOT GANGLION; OF-FUNCTION MUTATION; PRIMARY SENSORY NEURONS; GATED NA+ CHANNELS; SEVERE MYOCLONIC EPILEPSY; SIMPLE FEBRILE SEIZURES; BLIND CROSSOVER TRIAL;

D O I：

10.1016/j.nurt.2009.08.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Drugs that block voltage-gated sodium channels are efficacious in the management of neuropathic pain. Accordingly, this class of ion channels has been a major focus of analgesic research both in academia and in the pharmaceutical/biotechnology industry. In this article, we review the history of the use of sodium channel blockers, describe the current status of sodium channel drug discovery, highlight the challenges and hurdles to attain sodium channel subtype selectivity, and review the potential usefulness of selective sodium channel blockers in neuropathic pain.

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收藏

页码：663 / 678

页数：16

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