Context features of transcription factor binding site sequences: Relation to DNA-binding domain classification

被引：0

作者：

Orlov, Yu. L. ^{[1
]}

Proscura, A. L. ^{[1
]}

Vityaev, E. E. ^{[1
]}

Arrigo, P. ^{[1
]}

机构：

[1] SB RAS, Inst Cytol & Genet, Novosibirsk, Russia

来源：

Proceedings of the Fourth International Conference on Bioinformatics of Genome Regulation and Structure, Vol 1 | 2004年

关键词：

transcription factor binding sites; DNA-binding domains; classification; gene expression regulation; context features; complexity;

D O I：

暂无

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: Classification of eukaryotic transcription factor binding sites (TFBS) by context features of DNA sequences is of importance for analysis gene transcription regulation. Growth of information volume for gene regulatory sequences makes it possible to reveal new statistical regularities,governing DNA-binding and gene expression regulation. Results: We search for sequence constraints connected with text complexity for core regions of transcription factor binding sites. The content of protein-binding nucleotide sequences is connected with DNA-binding domain classification. These finding suggest new approaches for TFBS classification and clusterization. Availability: the software available at http://wwwmgs.bionet.nsc.ru/mgs/programs/ low_complexity, database at http://wwwmgs.bionet.nsc.ru/mgs/gnw/trrd/, results and supplementary materials are available by request to the authors.

引用

页码：158 / 161

页数：4

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